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Critical Reviews™ in Immunology
IF: 1.352 5-Year IF: 3.347 SJR: 0.657 SNIP: 0.55 CiteScore™: 2.19

ISSN Print: 1040-8401
ISSN Online: 2162-6472

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.2016015691
pages 433-449

Mechanisms of Cytotoxic Lymphocyte-Mediated Apoptosis and Relationship with the Tumor Suppressor p53

Jerome Thiery
INSERM, U1186, Villejuif, France; Gustave Roussy Cancer Campus, Villejuif, France; and University Paris-Saclay, Faculty of Medicine, Le Kremlin Bicetre, France
Thouraya Ben Safta
INSERM, U1186, Villejuif, France; Gustave Roussy Cancer Campus, Villejuif, France; and University Paris-Saclay, Faculty of Medicine, Le Kremlin Bicetre, France
Linda Ziani
INSERM, U1186, Villejuif, France; Gustave Roussy Cancer Campus, Villejuif, France; and University Paris-Saclay, Faculty of Medicine, Le Kremlin Bicetre, France
Salem Chouaib
Thumbay Research Institute for Precision Medicine, Gulf Medical University, Ajman 4184, United Arab Emirates; INSERM UMR 1186, Integrative Tumor Immunology and Genetic Oncology, Gustave Roussy, EPHE, Faculty de Médecine University Paris-Sud, University Paris-Saclay, Villejuif F-94805, France

ABSTRACT

Cytotoxic T lymphocytes and natural killer cells are key effector cells in the immune response against intracellular infection and transformed cells. These killer cells induce multiple programs of cell death to achieve their function of eliminating their targets. In this review, we summarize our current understanding of the signaling pathways involved in target cells apoptosis triggered by the cytotoxic effector cells. We also discuss the role of an important player in the field of apoptosis, the well-known p53 tumor suppressor, in the modulation of cytotoxic lymphocyte-mediated cell death.


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