Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Immunology
IF: 1.352 5-Year IF: 3.347 SJR: 0.657 SNIP: 0.55 CiteScore™: 2.19

ISSN Print: 1040-8401
ISSN Online: 2162-6472

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.2016018175
pages 163-177

Natural IgM and the Development of B Cell-Mediated Autoimmune Diseases

Trang T. T. Nguyen
Center for Comparative Medicine, Graduate Group in Immunology, University of California, Davis, Davis, CA 95616, USA
Nicole Baumgarth
Center for Comparative Medicine, Graduate Group in Immunology, and Dept. Pathology, Microbiology & Immunology, University of California, Davis, Davis, CA 95616, USA

ABSTRACT

Most serum immunoglobulin M (IgM) is "natural IgM", which is produced apparently spontaneously by a distinct subset of B cells requiring no exogenous antigenic or microbial stimuli. Natural IgM is an evolutionarily conserved molecule and reacts with a variety of epitopes expressed on both self- and non-self antigens. It has long been understood that secreted (s) IgM contributes to the removal of altered self-antigens, such as apoptotic and dying cells. As we outline in this review, it is thought that this sIgM housekeeping function removes potential triggers of autoresponse induction. However, we recently demonstrated an unexpected and distinct role for sIgM in the control of autoreactive B cells: the regulation of bone marrow B cell development. The absence of sIgM blocked pro- to pre- B-cell transition and greatly altered the BCR repertoire of the developing B cells and the peripheral B-cell pools in genetically engineered mice. This finding strongly suggests that IgM is critical for B-cell central tolerance induction. Given that treatment of sIgM-deficient mice with polyclonal IgM corrected these developmental defects, therapeutic application of IgM could be of clinical relevance in the treatment of some B-cell−mediated autoimmune diseases.


Articles with similar content:

Metabolic Factors that Contribute to Lupus Pathogenesis
Critical Reviews™ in Immunology, Vol.36, 2016, issue 1
Ramya Sivakumar, Laurence Morel, Anton A. Titov, Wei Li, Seung-Chul Choi
T-Cell Receptor-Derived Peptides in Immunoregulation and Therapy of Retrovirally Induced Immunosuppression
Critical Reviews™ in Immunology, Vol.21, 2001, issue 1-3
Ian F. Robey, Ronald R. Watson, R. Tomas Sepulveda, Allen B. Edmundson, John J. Marchalonis
The Contribution of Thymic Stromal Abnormalities to Autoimmune Disease
Critical Reviews™ in Immunology, Vol.31, 2011, issue 3
Melanie N. Hince, Adrienne Calder, Anne L. Fletcher, Ann P. Chidgey, Richard L. Boyd
Immunometabolic Signaling Pathways Contribute to Macrophage and Dendritic Cell Function
Critical Reviews™ in Immunology, Vol.36, 2016, issue 5
Aditya P. Dandekar, Lucas T. Jennelle, Tshifhiwa Magoro, Young S. Hahn
Function of Neurotrophic Factors Beyond the Nervous System: Inflammation and Autoimmune Demyelination
Critical Reviews™ in Immunology, Vol.29, 2009, issue 1
Ralf Linker, Ralf Gold, Fred Luhder