Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Immunology
IF: 1.352 5-Year IF: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN Print: 1040-8401
ISSN Online: 2162-6472

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v17.i3-4.20
pages 285-299

Major Histocompatibility Complex (MHC) Class I Recognition by Natural Killer Cells

Christian Dohring
Basel Institute for Immunology, Basel CH-4005, Switzerland
Marco Colonna
Basel Institute for Immunology, Basel CH-4005, Switzerland


NK cells express clonally distributed receptors specific for MHC class I molecules. Structurally, these receptors belong to the C-type lectin superfamily in mouse and to the immunoglobulin superfamily in human. Functionally, they can be distinguished as inhibitory or stimulatory. Inhibitory receptors block NK cell-mediated cytotoxicity upon binding to HLA class I ligands. This function is mediated by phosphorylation of cytoplasmic tyrosines, which recruit the protein tyrosine phosphatase SHP-1. Stimulatory receptors also bind HLA class I, lack cytoplasmic tyrosine-based motifs, and trigger NK cell-mediated cytotoxicity. All these receptors are characterized by a limited diversity allowing for sensitive detection of loss of MHC class I molecules on autologous transformed and virally infected cells.

Articles with similar content:

CD40 and Dendritic Cell Function
Critical Reviews™ in Immunology, Vol.23, 2003, issue 1-2
Ranjeny Thomas, Brendan O'Sullivan
Negative Regulation of T-Cell Function by PD-1
Critical Reviews™ in Immunology, Vol.24, 2004, issue 4
Yuan yuan Zha, Christian Blank, Thomas F. Gajewski
Ly-49 Receptors and Their Functions
Critical Reviews™ in Immunology, Vol.24, 2004, issue 5
Kerry J. Lavender, Brian J. Ma, Kevin P. Kane
Molecular Interactions Between Dendritic Cells and Salmonella: Escape from Adaptive Immunity and Implications on Pathogenesis
Critical Reviews™ in Immunology, Vol.25, 2005, issue 5
Mirentxu I. Iruretagoyena, Alexis M. Kalergis, Jaime A. Tobar, Susan M. Bueno
Regulation of NK Cell Repertoire and Function in the Liver
Critical Reviews™ in Immunology, Vol.31, 2011, issue 1
Peter D. Krueger, Huihong Qiao, Matthew G. Lassen, Young S. Hahn