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Critical Reviews™ in Immunology
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ISSN Online: 2162-6472

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Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.2017020284
pages 485-510

The Role of the Transcription Factor Ets1 in Lupus and Other Autoimmune Diseases

Lee Ann Garrett-Sinha
Department of Biochemistry, State University of New York at Buffalo, Buffalo, NY 14203
Alyssa Kearly
Department of Biochemistry, State University of New York at Buffalo, Buffalo, NY 14203
Anne B. Satterthwaite
Department of Internal Medicine, Rheumatic Diseases Division; Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390

ABSTRACT

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by excess B- and T-cell activation, the development of autoantibodies against self-antigens including nuclear antigens, and immune complex deposition in target organs, which triggers an inflammatory response and tissue damage. The genetic and environmental factors that contribute to the development of SLE have been studied extensively in both humans and mouse models of the disease. One of the important genetic contributions to SLE development is an alteration in the expression of the transcription factor Ets1, which regulates the functional differentiation of lymphocytes. Here, we review the genetic, biochemical, and immunological studies that have linked low levels of Ets1 to aberrant lymphocyte differentiation and to the pathogenesis of SLE.


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