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Critical Reviews™ in Immunology
IF: 1.352 5-Year IF: 3.347 SJR: 0.657 SNIP: 0.55 CiteScore™: 2.19

ISSN Print: 1040-8401
ISSN Online: 2162-6472

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v28.i4.10
pages 269-279

Regulation of Airway Innate and Adaptive Immune Responses: The IL-17 Paradigm

Li-Yin Hung
Center for Comparative Respiratory Biology and Medicine, University of California, Davis, CA95616
Sharlene Velichko
Center for Comparative Respiratory Biology and Medicine, University of California, Davis, CA95616
Fei Huang
Center for Comparative Respiratory Biology and Medicine, University of California, Davis, CA95616
Philip Thai
Center for Comparative Respiratory Biology and Medicine, University of California, Davis, CA95616
Reen Wu
Center for Comparative Respiratory Biology and Medicine, University of California, USA

ABSTRACT

IL-17 is a proinflammatory cytokine produced by immune cells. Its significance in host defense and disease development has been demonstrated in various infection and autoimmune models. Recently, additional studies have shown that IL-17 is also important in modulating airway immune response in several aspects. Along with the well-established Th1/Th2 model, new discoveries regarding the Th17 lineage and IL-17 functions have added an extra twist to the already complicated cytokine network that regulates airway immunity. The IL-17 receptor is expressed on blood cells, as well as on structural cells such as the epithelial cells in the airway. Therefore, the effect of IL-17 on airway immunity is very broad, covering both the innate and the adaptive aspects. In this review, we summarize the findings of recent studies on IL-17 signaling and function in pulmonary immune response, and the implications of IL-17 in disease pathogenesis.


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