Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Therapeutic Drug Carrier Systems
IF: 2.9 5-Year IF: 3.72 SJR: 0.736 SNIP: 0.551 CiteScore™: 2.43

ISSN Print: 0743-4863
ISSN Online: 2162-660X

Volumes:
Volume 36, 2019 Volume 35, 2018 Volume 34, 2017 Volume 33, 2016 Volume 32, 2015 Volume 31, 2014 Volume 30, 2013 Volume 29, 2012 Volume 28, 2011 Volume 27, 2010 Volume 26, 2009 Volume 25, 2008 Volume 24, 2007 Volume 23, 2006 Volume 22, 2005 Volume 21, 2004 Volume 20, 2003 Volume 19, 2002 Volume 18, 2001 Volume 17, 2000 Volume 16, 1999 Volume 15, 1998 Volume 14, 1997 Volume 13, 1996 Volume 12, 1995

Critical Reviews™ in Therapeutic Drug Carrier Systems

DOI: 10.1615/CritRevTherDrugCarrierSyst.2018019429
pages 195-292

Current Perspectives on Novel Drug Carrier Systems and Therapies for Management of Pancreatic Cancer: An Updated Inclusive Review

Rohit R. Bhosale
JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru
Hosahalli Veerabhadrappa Gangadharappa
Department of Pharmaceutics, JSS Academy of Higher Education and Research, Mysuru 570015, Karnataka, India
Devegowda Vishakante Gowda
Department of Pharmaceutics, JSS Academy of Higher Education and Research, Mysuru 570015, Karnataka, India
Riyaz Ali Mahafez Ali Osmani
Department of Pharmaceutics, JSS Academy of Higher Education and Research, Mysuru 570015, Karnataka, India
Rudra Vaghela
Department of Pharmaceutics, JSS Academy of Higher Education and Research, Mysuru 570015, Karnataka, India
Parthasarathi Keshavarao Kulkarni
Department of Pharmaceutics, JSS Academy of Higher Education and Research, Mysuru 570015, Karnataka, India
Koganti Venkata Sairam
Department of Pharmaceutical Chemistry, JSS Academy of Higher Education and Research, Mysuru 570015, Karnataka, India
Bannimath Gurupadayya
Department of Pharmaceutical Chemistry, JSS Academy of Higher Education and Research, Mysuru 570015, Karnataka, India

ABSTRACT

Pancreatic cancer (PC) is one of the most fatal solid tumors, resulting in more than 250,000 deaths per year globally. It is the eighth leading cause of death from cancer in men and women throughout the world and is now third leading cause of cancer-related deaths in the United States. In addition, the worldwide occurrence of PC ranges from 1 to 10 cases per 100,000 people, indicating a higher incidence in developed countries. Most patients with locally advanced or metastatic disease are not candidates for curative resection due to enormously poor prognosis. Substantial efforts have been taken during the past decade to distinguish better treatments in the absence of efficient screening methods. Regardless of wide-ranging efforts, various systems and therapies have shown insufficient efficacy for PC patients. Therefore, the development of novel drug delivery systems, strategies, and diverse therapeutic approaches to improve the range of active molecules for the treatment of PC is critical. Currently, cancer research focuses on improving the treatment of PC via diverse novel drug delivery systems of chemotherapeutic agents. These novel drug delivery systems consist of nanoparticles and liposomes. Strategies or therapeutic approaches intended for PC include radiation therapy, ablation therapy, and gene therapy. These systems and approaches can carry the drug molecules to targeted cancer cells to enhance the effectiveness of tumor penetration. The present review encloses existing novel drug carrier systems and approaches for PC management.


Articles with similar content:

Lessons Learned from Gemcitabine: Impact of Therapeutic Carrier Systems and Gemcitabine’s Drug Conjugates on Cancer Therapy
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.34, 2017, issue 1
Sathish Dyawanapelly, Animesh Kumar, Manish K. Chourasia
Newer Trends in Pancreatic Cancer Treatment: Genetic Alterations and the Role of Immune Therapeutic and Targeted Therapies
Critical Reviews™ in Oncogenesis, Vol.24, 2019, issue 2
Abdul Kareem Khan, Mamoon Ur Rashid, Ishtiaq Hussain, Sarfraz Ahmad, Hasan Badar, Muhammad Muzammil, Sundas Jehanzeb, Deepika Sarvepalli, Muhammad Talha Khan, Asad ur Rahman, Waqas Ullah
Liposomes a Vesicular Nanocarrier: Potential Advancements in Cancer Chemotherapy
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.29, 2012, issue 5
Pramod Kumar, Arvind Gulbake, Sanjay Kumar Jain
Polymeric Immunonanoparticles Mediated Cancer Therapy: Versatile Nanocarriers for Cell-Specific Cargo Delivery
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.35, 2018, issue 1
Niyati S. Acharya, Namdev L. Dhas, Ritu R. Kudarha, Sanjeev R. Acharya
Oral Squamous Cell Carcinoma: Current Treatment Strategies and Nanotechnology-Based Approaches for Prevention and Therapy
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.33, 2016, issue 4
Munira Momin, Chintan Bhavsar, Sankalp A. Gharat