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Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2

ISSN Print: 0893-9675
ISSN Online: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.v12.i3-4.20
pages 205-223

Emerging Technologies for Genome-wide DNA Methylation Profiling in Cancer

Izuho Hatada
Laboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi 371-8511 Japan

ABSTRACT

Genome-wide epigenetics, namely, epigenomics, is one of the current frontiers in cancer genomics. Epigenetic silencing of tumor-suppressor genes plays an important role in the pathogenesis of most cancers. Several technologies are emerging for the genome-wide profiling of DNA methylation to find new tumor-suppressor genes and predictions for clinical phenotypes in individual patients.


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