Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2

ISSN Print: 0893-9675
ISSN Online: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.v7.i3-4.60
pages 245-260

Myb-lnduced Transformation

Linda Wolff
Laboratory of Cellular Oncology, National Cancer Institute


The c-myb protooncogene has been implicated in the development of avian and murine hematopoietic neoplasms of the myeloid and lymphoid lineages. The transcription factor encoded by this gene has a dual function in oncogenesis because it regulates genes that prevent apoptosis and genes involved in cellular proliferation, c-myb has repeatedly been a target of retroviral insertional mutagenesis. The most common mechanism by which retroviruses activate c-myb's oncogenic potential is by providing transcriptional control that results in constitutive expression, a feature that is consistent with the demonstration that ectopic expression of c-myb can prevent growth arrest of differentiating hematopoietic cells. In a less common mechanism of activation, carboxyl(C)-terminal truncation renders the c-Myb protein more stable and active in transcriptional transactivation. Interestingly, the ability of v-Myb, a product of the avian myeloblastosis virus (AMV), to cause rapid transformation of cells in vivo and in vitro can be explained by the combined effects of deregulated expression through the retroviral LTR, N- and C-terminal truncation, and activating mutations in its DNA binding domain. Although c-myb's involvement in human leukemia has been suggested, it has never been clearly established and should be investigated further.

Articles with similar content:

The Cbl Family of Signal Transduction Molecules
Critical Reviews™ in Oncogenesis, Vol.8, 1997, issue 4
Linda Smit , Jannie Borst
Oncogene- and Tumor-Suppressor Gene-Related Proteins in Plants and Fungi
Critical Reviews™ in Oncogenesis, Vol.7, 1996, issue 1-2
Peter Loidl, Adele Loidl
The Cbl Protooncogene Product: From an Enigmatic Oncogene to Center Stage of Signal Transduction
Critical Reviews™ in Oncogenesis, Vol.8, 1997, issue 2-3
Patrice Douillard, Mark L. Lupher, Jr., Nancy L. Lill, Satoshi Ota, Christopher E. Andoniou, Hamid Band, Navin Rao, Sachiko Miyake
The Role of Myb Proteins in Normal and Neoplastic Cell Proliferation
Critical Reviews™ in Oncogenesis, Vol.5, 1994, issue 4
Roger Watson, Jonathan Lyon, Cleo Robinson
RUNX3-Mediated Immune Cell Development and Maturation
Critical Reviews™ in Immunology, Vol.38, 2018, issue 1
Istvan Szatmari, Tamas Imre Csuth, Pal Boto