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Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2.2

ISSN Print: 0893-9675
ISSN Online: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.2018029633
pages 55-59

The Importance of Cancer Stem Cells in Gastrointestinal Cancers

Duygu Altinok Dindar
Health Institute of Turkey, Turkish Cancer Institute, 06434, Ankara, Turkey
Gulsah Albayrak
Department of Medical Biology, Faculty of Medicine, Ufuk University, Balgat, 06520, Ankara, Turkey
Ahmet Ozet
Department of Medical Oncology, Faculty of Medicine, Gazi University, Besevler, 06510, Ankara, Turkey

ABSTRACT

Cancer is a major cause of death worldwide. Gastrointestinal (GI) cancers are still an important cause of tumor-related deaths. Conventional therapeutic approaches like surgery, chemotherapy, and radiation therapy are indispensable but insufficient. Despite the advances in immunotherapy and other conventional treatment strategies, some might argue that we are still far from curing cancer. Cancer stem cells (CSCs) might be to blame. Because sequencing technologies are moving fast in this precision-medicine era, molecular testing of tumors, circulating tumor cells, and CSCs have important implications for treatment decisions. Biomarkers offer prognostic values and targeted therapy availabilities as molecular predictive factors. CSCs are considered biomarkers of tumorigenesis development, metastasis, and recurrence. In this review, we summarize the important issues over CSCs and the development of new drugs that target GI CSCs.


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