Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2

ISSN Print: 0893-9675
ISSN Online: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.2016017124
pages 65-73

Intralesional Immunotherapy for Metastatic Melanoma: The Oldest and Newest Treatment in Oncology

Mark B. Faries
John Wayne Cancer Institute, 2200 Santa Monica Blvd, Santa Monica, CA 90404


The last few years have yielded exciting developments in immunotherapy for cancer. The promise of cancer immunotherapy has been well known for many years, but had generally produced limited or inconsistent benefit to patients. Intralesional therapies, which are in fact one of the oldest forms of immunotherapy, are also demonstrating benefits in the modern age. This review discusses the origins of intralesional immunotherapy and its underlying rationale. It also discusses the reemergence of this mode of therapy into the modern era, which is where Donald L. Morton, subject of this edition of the journal, plays a major role. The review also discusses current areas of investigation. Given the intuitive advantages of this strategy and the demonstrated, expanding areas of clinical responses, it is likely that intralesional immunotherapy will remain a useful component of cancer treatment into the future.

Articles with similar content:

Non-Major Histocompatibility Complex Rheumatoid Arthritis Susceptibility Genes
Critical Reviews™ in Immunology, Vol.31, 2011, issue 2
Saleh M. Ibrahim, Manfred Kunz
Adoptive Immunotherapy of Cancer Using Chimeric Antigen Receptor−Engineered T Cells
Forum on Immunopathological Diseases and Therapeutics, Vol.5, 2014, issue 1-2
John Maher, Daniela Achkova
The Microbiome of Oral Cancer
Critical Reviews™ in Oncogenesis, Vol.23, 2018, issue 3-4
Edward J. Shillitoe
Treating Colorectal Cancer with Western and Chinese Medicine
Forum on Immunopathological Diseases and Therapeutics, Vol.2, 2011, issue 4
C. Junghanss, M. Leithauser, Hans Lampe, M. Freund
Regulatory Mechanism of The Induction of Regulatory T Cells through Growth Factors Released by Human Mesenchymal Stem Cells
Critical Reviews™ in Immunology, Vol.38, 2018, issue 6
Yoshiya Tanaka, Masahiro Kondo, Shingo Nakayamada, Ippei Miyagawa