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Critical Reviews™ in Oncogenesis
SJR: 0.631 SNIP: 0.503 CiteScore™: 2

ISSN Print: 0893-9675
ISSN Online: 2162-6448

Critical Reviews™ in Oncogenesis

DOI: 10.1615/CritRevOncog.2017021314
pages 1-11

YY1 Is an Inducer of Cancer Metastasis

Wenmeng Wang
College of Life Science, Northeast Forestry University, Harbin, China
Dangdang Li
College of Life Science, Northeast Forestry University, Harbin, China
Guangchao Sui
College of Life Science, Northeast Forestry University, Harbin, China; Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina


Yin Yang 1 (YY1) is a member of the GLI–Kruppel family of zinc finger proteins that plays vital roles in many biological processes, especially tumorigenesis. To date, ample evidence suggests a critical regulatory role of YY1 in tumor cell metastasis. The potential of YY1 as a valuable biomarker for cancer metastasis has been increasingly known. Here, we review the studies related to the expression, regulatory network, and clinical application of YY1 in cancer metastasis. We first summarize YY1 expression patterns in metastatic tumors. We then elaborate YY1-regulated mechanisms on five aspects, including epithelial–mesenchymal transition, cell migration and invasion, stemness, polyploidy, and genomic stability. Finally, we discuss the correlation between YY1 expression and clinical outcomes and therapeutic potential of YY1 in cancer treatment. Based on this review, we conclude that YY1 is a bona fide inducer of cancer metastasis and can serve as a clinical biomarker and therapeutic target for cancer treatment.

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