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Critical Reviews™ in Biomedical Engineering
SJR: 0.26 SNIP: 0.375 CiteScore™: 1.4

ISSN Print: 0278-940X
ISSN Online: 1943-619X

Critical Reviews™ in Biomedical Engineering

DOI: 10.1615/CritRevBiomedEng.v39.i5.10
pages 361-362


Mahendra Kavdia
Department of Biomedical Engineering, Wayne State University, Detroit, Michigan
Nikolaos M. Tsoukias
Department of Biomedical Engineering, Florida International University, Miami, FL


This issue of Journal of Critical Reviews in Biomedical Engineering contains five review articles on the current state and contribution of modeling of signal transduction at different scales in cardiovascular systems. These review papers address diverse issues such as oxidative and nitrosative stress, electrophysiology, cell signaling and metabolism, the regulation of local perfusion and oxygenation, several signaling pathways in the microcirculation that involve NO, and calcium and mitochondrial energy transduction. They highlight the contribution of computational modeling to our understanding of cardiovascular systems from molecules to whole organ and in physiology and pathophysiology and therapeutic approaches. The reviews provide a reader the comprehensive view of challenges and opportunities in modeling in cardiovascular systems.

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