Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Plasma Medicine
SJR: 0.198 SNIP: 0.183 CiteScore™: 0.57

ISSN Print: 1947-5764
ISSN Online: 1947-5772

Plasma Medicine

DOI: 10.1615/PlasmaMed.2018020991
pages 163-175

Electromagnetic Fields Induce Frequency-Dependent Radioprotection and Radiosensitization in In Vitro Cell Cultures

Angela Chinhengo
Division of Radiobiology, Department of Medical Imaging and Clinical Oncology, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa
Antonio Serafin
Division of Radiobiology, Department of Medical Imaging and Clinical Oncology, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa
Bianca Hamman
Division of Radiobiology, Department of Medical Imaging and Clinical Oncology, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa
John Akudugu
Division of Radiobiology, Department of Medical Imaging and Clinical Oncology, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa

ABSTRACT

The incidence of Kaposi sarcoma comorbidity in patients with human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) is high. These patients tend to be more sensitive to ionizing radiation, making the management of their cancer with radiotherapy difficult. Hence, noninvasive methods to sensitize cancer cells and reduce therapeutic doses are needed. In this article, the effect of an electromagnetic field (EMF) of 27.125 MHz, modulated by 100- and 1000-Hz fields, on the radiosensitivity of Chinese hamster lung fibroblasts (V79) and human melanoma cells (MeWo) was evaluated using the colony-forming assay. Induced magnetic flux densities in cell cultures ranged from 0.05 to 0.25 μT. Preexposure of V79 to both modulated fields had no effect on their radiosensitivity, if irradiation followed within 2 h or at 6 h. Significant radiosensitization was observed when X-rays were administered 4 h after EMF exposure. Preexposure of MeWo to the 100-Hz-modulated field resulted in a significant radioprotection when irradiation followed within 6 h. However, treatment of these cells with the 1000-Hz-modulated field significantly potentiated the effect of X-rays. When cells were irradiated before EMF exposure, V79 cells were marginally protected by the 100-Hz-modulated field and sensitized by the 1000-Hz-modulated field. In contrast, the melanoma cells were slightly protected by the 1000-Hz-modulated field and sensitized by the 100-Hz-modulated field. Informed combination of low-medium frequency electromagnetic fields and radiotherapy might be beneficial in cancer management, especially in HIV-positive patients.


Articles with similar content:

A Randomized, Placebo-Controlled, Multicenter Study of Ganoderma lucidum (W.Curt.:Fr.) Lloyd (Aphyllophoromycetideae) Polysaccharides (Ganopoly®) in Patients with Advanced Lung Cancer
International Journal of Medicinal Mushrooms, Vol.5, 2003, issue 4
Guoliang Chen, Jingxian Ye, Yihuai Gao, Shufeng Zhou, Xihu Dai
Comparison of Cellular Sensitivity to a Split Radiation Dose and a Combination of a Single Radiation Dose and Electromagnetic Field Exposure
Plasma Medicine, Vol.9, 2019, issue 1
Antonio Serafin, John Akudugu, Angela Chinhengo
A Phase I/II Study of a Ganoderma lucidum (Curt.: Fr.) P. Karst. Extract (Ganopofy) in Patients with Advanced Cancer
International Journal of Medicinal Mushrooms, Vol.4, 2002, issue 3
Guoliang Chen, Jingxian Ye, Yihuai Gao, Shufeng Zhou, Xihu Dai
Photoprotective Effect of Calluna vulgaris Extract Against UVB-Induced Phototoxicity in Human Immortalized Keratinocytes
Journal of Environmental Pathology, Toxicology and Oncology, Vol.30, 2011, issue 4
Olga Soritau, Corina Bianca Tatomir, Gabriela Chereches, Ion Dan Postescu, Maria Perde-Schrepler, Ioana Carmen Brie, Laurian Vlase, Adriana Filip, Otilia Barbos, Eva Fischer-Fodor, Piroska Virag
Avelumab: A Novel Anti-PD-L1 Agent in the Treatment of Merkel Cell Carcinoma and Urothelial Cell Carcinoma
Critical Reviews™ in Immunology, Vol.38, 2018, issue 3
Amanda Teets, Linda Pham, Rahul Deshmukh, Lana Hochmuth, Emma Lan Tran