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Critical Reviews™ in Eukaryotic Gene Expression
IF: 1.841 5-Year IF: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Print: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2017019713
pages 267-275

Association of ERCC1 Polymorphisms with the Risk of Colorectal Cancer: A Meta-Analysis

Jianfeng Chen
Department of General Surgery, The Affiliated Yiwu Hospital of Wenzhou Medical University, Yiwu 322000, China
Ningjie Sun
Department of General Surgery, The Affiliated Yiwu Hospital of Wenzhou Medical University, Yiwu 322000, China
Gang Hu
Department of General Surgery, The Affiliated Yiwu Hospital of Wenzhou Medical University, Yiwu 322000, China
Xiansheng Chen
Department of General Surgery, Yiwu Hospital, Wenzhou Medical University, Yiwu 322000, China
Jiansong Jiang
Department of General Surgery, The Affiliated Yiwu Hospital of Wenzhou Medical University, Yiwu 322000, China
Haiming Wu
Department of General Surgery, The Affiliated Yiwu Hospital of Wenzhou Medical University, Yiwu 322000, China
Gaojian Luo
Department of General Surgery, Yiwu Hospital, Wenzhou Medical University, Yiwu 322000, China

ABSTRACT

The ERCC1 enzyme in the nucleotide excision repair (NER) pathway plays a vital role in DNA repair. Numerous epidemiological studies have evaluated the association between ERCC1 polymorphisms and the risk of colorectal cancer (CRC), with conflicting results. To evaluate the potential associations, we conducted a meta-analysis. Eligible studies were identified by searching electronic databases. The odds ratio (OR) and 95% confidence interval (CI) were applied to assess the associations between ERCC1 polymorphisms and CRC risk. The meta-analysis results revealed significant associations between ERCC1 rs3212986 and rs2298881 polymorphisms and CRC risk (rs3212986 GG vs CC: OR = 1.66, 95% CI = 1.13–2.44; CG vs CC: OR = 1.12, 95% CI = 0.82–1.55; the dominant model: OR = 1.21, 95% CI = 0.86–1.71; the recessive model: OR = 1.59, 95% CI = 1.09–2.31; rs2298881 CC vs. AA: OR = 2.04, 95% CI = 1.29–3.23; AC vs. AA: OR = 1.19, 95% CI = 0.91–1.56; the dominant model: OR = 1.33, 95% CI = 1.04–1.72; the recessive model: OR = 1.91, 95% CI = 1.22–3.00). However, no association with CRC risk was identified for ERCC1 polymorphisms rs11615 and rs2276466. In conclusion, these findings identified no association between rs11615 and rs2276466 polymorphisms and CRC susceptibility, but the data indicate that ERCC1 rs3212986 and rs2298881 polymorphisms may increase susceptibility to CRC. Large and well-designed studies are needed to further validate our findings.


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