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Critical Reviews™ in Eukaryotic Gene Expression
IF: 1.841 5-Year IF: 1.927 SJR: 0.649 SNIP: 0.516 CiteScore™: 1.96

ISSN Print: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukaryotGeneExpr.2017020525
pages 347-354

Association between the Epithelial Cadherin − 160C/A Polymorphism and Colorectal Cancer Risk: Evidence from a Meta-Analysis

Ningjie Sun
Department of General Surgery, The Affiliated Yiwu Hospital of Wenzhou Medical University, Yiwu 322000, China
Jianfeng Chen
Department of General Surgery, The Affiliated Yiwu Hospital of Wenzhou Medical University, Yiwu 322000, China
Gang Hu
Department of General Surgery, The Affiliated Yiwu Hospital of Wenzhou Medical University, Yiwu 322000, China
Xiansheng Chen
Department of General Surgery, The Affiliated Yiwu Hospital of Wenzhou Medical University, Yiwu 322000, China
Jiansong Jiang
Department of General Surgery, The Affiliated Yiwu Hospital of Wenzhou Medical University, Yiwu 322000, China
Lei Zhang
Department of General Surgery, The Affiliated Yiwu Hospital of Wenzhou Medical University, Yiwu 322000, China
Haiming Wu
Department of General Surgery, The Affiliated Yiwu Hospital of Wenzhou Medical University, Yiwu 322000, China

ABSTRACT

The aim of the present study was to assess the association between the epithelial cadherin (CDH1) –160C/A polymorphism and colorectal cancer (CRC) using a meta-analysis. A literature search of PubMed, Embase, and Web of Science databases was performed for relevant studies. Statistical analyses were carried out using Stata 12.0 to combine all of the relevant studies. Odds ratio (OR) with 95% confidence interval (CI) values were applied to evaluate the strength of the association. Eight studies with 7231 cases and 7080 controls were included. The meta-analysis results showed that the CDH1 –160C/A polymorphism was significantly associated with CRC risk (AA vs. CC: OR = 0.98, 95% CI = 0.71–1.36; CA vs. CC: OR = 0.92, 95% CI = 0.86–0.99; dominant model: OR = 1.01, 95% CI = 0.81–1.26; recessive model: OR = 0.91, 95% CI = 0.81–1.02). In the subgroup analysis based on ethnicity, significant association was found between the CDH1 –160C > A polymorphism and CRC risk in Caucasians. In conclusion, the CDH1 –160C/A polymorphism may be a susceptible predictor for the risk of CRC in Caucasians.


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