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Critical Reviews™ in Eukaryotic Gene Expression
IF: 2.156 5-Year IF: 2.255 SJR: 0.649 SNIP: 0.599 CiteScore™: 3

ISSN Print: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v21.i4.60
pages 363-377

Mesenchymal Stem Cells in the Aging and Osteoporotic Population

Francesca Veronesi
University of Bologna
Paola Torricelli
Preclinical and Surgical Studies Laboratory, Codivilla-Putti Research Institute - Rizzoli Orthopedic Institute, Bologna-Italy; Laboratory of Biocompatibility, Technological Innovations and Advanced Therapies, Department Rizzoli RIT- Rizzoli Orthopedic
Veronica Borsari
Laboratory of Biocompatibility, Technological Innovations and Advanced Therapies, Department Rizzoli RIT- Rizzoli Orthopedic Institute, Bologna-Italy
Matilde Tschon
Preclinical and Surgical Studies Laboratory, Codivilla-Putti Research Institute - Rizzoli Orthopedic Institute, Bologna-Italy; Laboratory of Biocompatibility, Technological Innovations and Advanced Therapies, Department Rizzoli RIT- Rizzoli Orthopedic
Lia Rimondini
Laboratory of Biomedical and Dental Materials, Department of Health Sciences, Universita del Piemonte Orientale "A. Avogadro", (NO), Italy; Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali (INSTM), (FI), Italy
Milena Fini
Laboratory of Preclinical and Surgical Studies, Rizzoli Orthopedic Institute, Bologna, Italy

ABSTRACT

Because of their ability to self-renew and differentiate, mesenchymal stem cells (MSCs) are the in vivo source for replacing lost cells in high-turnover tissues during the life of an organism. MSCs have osteogenic potential and can be eligible for the repair and maintenance of the skeleton, thus they are very attractive for tissue engineering and regenerative medicine approaches. However, many changes in their behavior, caused by aging and bone disease, have been reported in the literature. These changes, which affect MSC self-renewal ability and differentiation potentiality, are related to cell proliferation, differentiation, cell cycle phases (depending on gene modification), and cytokine and growth factor production. This review summarizes the literature related to intrinsic and extrinsic characteristics of human bone marrow or adipose tissue MSCs during aging and osteoporosis. Although some studies reveal contrasting results, the results of this review suggest that the cellular modifications due to aging and osteoporosis should be carefully considered in relation to the use of MSCs for therapeutic application.


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