Published 6 issues per year
ISSN Print: 1045-4403
ISSN Online: 2162-6502
Indexed in
The Impacts of miRNAs in Glioblastoma Progression
ABSTRACT
miRNAs are short noncoding RNA sequences that cause translational repression or mRNA degradation. A growing number of studies have sought new biomarkers in GBM that will be important in disease progression and prognosis and as potential therapeutic targets. miRNA-profiling studies in glioblastoma patients have found that aberrant miRNA expression can be used as a target to develop new biomarkers for disease detection and for determining prognosis or therapeutic response. In evaluating the tumor or its therapeutic response, genetic abnormalities such as mutations, epigenetic abnormalities, and aberrant miRNA expressions can be useful markers. This review summarizes the known miRNAs according their therapeutic importance and their use as disease progression biomarkers.
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Zhang Cong, Yang Xiuqin, Fu Chen, Liu Xin, Combination with TMZ and miR-505 inhibits the development of glioblastoma by regulating the WNT7B/Wnt/β-catenin signaling pathway, Gene, 672, 2018. Crossref
-
Tian Tian, Mingyi Ma, Qiu Xia, Qiu Yang, MicroRNA-101 reverses temozolomide resistance by inhibition of GSK3β in glioblastoma, Oncotarget, 7, 48, 2016. Crossref
-
Peng Tao, Wang Tiejun, Liu Guohui, Zhou Lixiang, Teng Zenghui, Effects of miR-373 Inhibition on Glioblastoma Growth by Reducing Limk1 In Vitro, Journal of Immunology Research, 2020, 2020. Crossref
-
Muñoz-Hidalgo Lisandra, San-Miguel Teresa, Megías Javier, Serna Eva, Calabuig-Fariñas Silvia, Monleón Daniel, Gil-Benso Rosario, Cerdá-Nicolás Miguel, López-Ginés Concha, The Status of EGFR Modulates the Effect of miRNA-200c on ZEB1 Expression and Cell Migration in Glioblastoma Cells, International Journal of Molecular Sciences, 22, 1, 2020. Crossref
-
Chen Peng, Zhang Guangying, Zhou Qin, Li Zhanzhan, Plasma microRNA-720 may predict prognosis and diagnosis in glioma patients, Bioscience Reports, 40, 7, 2020. Crossref
-
Balaji E Vignesh, Kumar Nitesh, Satarker Sairaj, Nampoothiri Madhavan, Zinc as a plausible epigenetic modulator of glioblastoma multiforme, European Journal of Pharmacology, 887, 2020. Crossref
-
Salmani Tayyebali, Ghaderian Sayyed Mohammad Hossein, Hajiesmaeili Mohammadreza, Rezaeimirghaed Omidvar, Hoseini Mahshid Sadat, Rakhshan Azadeh, Nasiri Mohammad Javad, Ghaedi Hamid, Akbarzadeh Reza, Hsa‐miR‐27a‐3p and epidermal growth factor receptor expression analysis in glioblastoma FFPE samples , Asia-Pacific Journal of Clinical Oncology, 17, 5, 2021. Crossref
-
Sun Jianrui, Wang Lin, HOXA-AS2 enhances GBM cell malignancy by suppressing miR-2116-3p thereby upregulating SERPINA3, BMC Cancer, 22, 1, 2022. Crossref
-
Gatto Lidia, Franceschi Enrico, Di Nunno Vincenzo, Tosoni Alicia, Lodi Raffaele, Brandes Alba Ariela, Liquid Biopsy in Glioblastoma Management: From Current Research to Future Perspectives, The Oncologist, 26, 10, 2021. Crossref