Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Eukaryotic Gene Expression
IF: 1.841 5-Year IF: 1.927 SJR: 0.627 SNIP: 0.516 CiteScore™: 1.96

ISSN Print: 1045-4403
ISSN Online: 2162-6502

Critical Reviews™ in Eukaryotic Gene Expression

DOI: 10.1615/CritRevEukarGeneExpr.v9.i3-4.20
pages 175-182

Evolution of Transcriptional Control from Prokaryotic Beginnings to Eukaryotic Complexities

Lili Huang
Dana Farber Cancer Institute, 44 Binney St., Boston, MA 02115
Rong J. Guan
Dana Farber Cancer Institute, 44 Binney St., Boston, MA 02115
Arthur B. Pardee
Dana Farber Cancer Institute, 44 Binney St., Boston, MA 02115

ABSTRACT

Mechanisms for regulating gene transcription became increasingly complex as organisms evolved. In prokaryotes the relatively simple mechanism of repression is based on a few proteins that bind to specific DNA sequences in a ligand-dependent fashion. In eukaryotes large complexes that include ligand binding proteins regulate transcription. Lower eukaryotes developed an additional level of control based on protein complexes that include modifying enzymes. The DNA/histone complex, in combination with gene-specific transcriptional factors, is the basis of gene regulation in eukaryotes. Higher eukaryotes took regulation a level further by methylating CpGs in promoter sequences of DNA, thereby allowing binding of histone deacetylases and inhibiting transcription. Finally, long-lasting "superrepression" provides another mechanism for coordinate transcriptional regulation of large blocks of genes.


Articles with similar content:

Interrelationships between Nuclear Structure and Ligand-Activated Intracellular Receptors
Critical Reviews™ in Eukaryotic Gene Expression, Vol.6, 1996, issue 2-3
Thomas S. Ruh, Mary F. Ruh, Robert Dunn, II
Caught in the Act: Binding of Ku and PARP to MARs Reveals Novel Aspects of Their Functional Interaction
Critical Reviews™ in Eukaryotic Gene Expression, Vol.10, 2000, issue 1
Terumi Kohwi-Shigematsu, Sanjeev Galande
The Estrogen Receptor Activity Cycle: Dependence on Multiple Protein-Protein Interactions
Critical Reviews™ in Eukaryotic Gene Expression, Vol.7, 1997, issue 1-2
Benjamin A. Lieberman
Physical Interaction of Human Yin Yang 1 Protein with DNA
Critical Reviews™ in Oncogenesis, Vol.22, 2017, issue 1-2
Małgorzata Figiel, Andrzej Górecki
Origin and Roles of Nuclear Matrix Proteins. Specific Functions of the MAR-Binding Protein MeCP2/ARBP
Critical Reviews™ in Eukaryotic Gene Expression, Vol.9, 1999, issue 3-4
Wolf H. Stratling, Fang Yu