Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v7.i3.840
pages 445-446

Medicinal Mushrooms: A New Source for Breast Cancer Therapeutics

Roumyana D. Petrova
Institute of Evolution, University of Haifa, Mount Carmel, Haifa; Migal-Galilee Technology Center, South Industrial Zone, Kiryat Shmona, Israel;Bulgarian Mycological Society, 23 Acad. G. Bonchev St., Sofia 1113, Bulgaria
Jamal A. Mahajna
Migal, Galilee Technology Center, Cancer Drug Discovery Program, Kiryat Shmona; Galilee Institute for Applied Research, Nazareth
Cvetomir M. Denchev
Institute of Botany, Bulgarian Academy of Sciences, Sofia, Bulgaria

ABSTRACT

It is known that advanced breast cancers do not respond well to chemotherapy, and their gene expression arouses uncontrolled growth. Although ER-positive breast cancers respond to hormonal therapy, the treatment of ER-negative cancers is more complicated. Despite the positive results of most of the chemotherapeutic regimes, cellular adaptations have enabled tumor cells to evade many of the chemotherapeutic drugs. One of these cellular chemoresistance factors is the transcription factor nuclear factor-kappa B (NF-κB). NF-κB can be such a target in breast cancer treatment, and its removal by an inhibitor can reverse the specific antiapoptosis of cancer cells. Therefore, NF-κB was selected as the main target in the present study.
Recently, the application of low-molecularweight compounds with fungal origin as natural therapeutics in cancer treatment has been gaining more attention. There are studies demonstrating that these biologically active fungal substances could be used as a novel pharmaceutical source in breast cancer therapy (Petrova et al., 2005). For instance, the caffeic acid phenethyl ester (CAPE), which specifically inhibits DNA binding of NF--κB and showed some promising results in human breast cancer MCF-7 cells, is found to be produced by Agaricus bisporus (J.E. Lange) Imbach, Lentinus edodes (Berk.) Singer, and Phellinus linteus (Berk. Et M.A. Curtis) Teng (Mattila et al., 2001; Nakamura et al., 2003). Low-molecular-weight compounds isolated from fruit bodies and spore extracts of Ganoderma lucidum (W.Curt.: Fr.) P. Karst. Also exhibited breast cancer and, more specifically, NF--κB inhibitory activity (Sliva et al., 2002; Sliva, 2003; Jiang et al., 2004).
Following these perspectives, we started a screening program of 75 strains of 67 species, kept in the Culture Collection of the Institute of Evolution, University of Haifa (HAI), belonging to different taxonomical and ecological groups. Mycelia were grown in submerged conditions for biomass production. Three organic solvents with different polarities (ethyl alcohol, ethyl acetate, and diethyl ether) were used for dry biomass extraction in order to isolate fungal secondary metabolites. Moreover, the culture broth, left after the mycelia filtration, was also extracted with ethyl acetate in order to receive bioactive compounds produced in the media during fungal growth.


Articles with similar content:

Potential Role of Medicinal Mushrooms in Breast Cancer Treatment: Current Knowledge and Future Perspectives
International Journal of Medicinal Mushrooms, Vol.7, 2005, issue 1&2
Solomon P. Wasser, Roumyana D. Petrova, Cvetomir M. Denchev, Eviatar D. Nevo, Jamal A. Mahajna
Screening Antitumor Activity of Low-Molecular-Weight Compounds Obtained from the Fruit Bodies of Family Agaricaceae Chevall. (Higher Basidiomycetes)
International Journal of Medicinal Mushrooms, Vol.7, 2005, issue 3
Marina Ya. Didukh, Jamal A. Mahajna
Medicinal Properties of Coprinoid Mushrooms (Basidiomycetes, Agaricales)
International Journal of Medicinal Mushrooms, Vol.7, 2005, issue 3
L. R. Melikyan, Susanna M. Badalyan, U. Kues, M. Navarro-Gonzalez
Antiproliferative, Immunostimulatory, and Anti-Inflammatory Activities of Extracts Derived from Mushrooms Collected in Haida Gwaii, British Columbia (Canada)
International Journal of Medicinal Mushrooms, Vol.21, 2019, issue 7
Chow H. Lee, Linda E. Tackaberry, Gurbind S. Deo, Jatinder Khatra, Keith N. Egger, Kerry Reimer, Hugues B. Massicotte, Sukhpreet Buttar, Wai Ming Li
Anti-Human Papillomavirus (HPV) 16 E6 Activity of Ling Zhi or Reishi Medicinal Mushroom, Ganoderma lucidum (W. Curt.: Fr.) P. Karst. (Aphyllophoromycetideae) Extracts
International Journal of Medicinal Mushrooms, Vol.12, 2010, issue 3
Noorlidah Abdullah, Nurhayati Zainal Abidin, Vikineswary Sabaratnam, Li Kuan Lai