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International Journal of Medicinal Mushrooms

Published 12 issues per year

ISSN Print: 1521-9437

ISSN Online: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Medicinal Mushroom Extracts Possess Differential Antioxidant Activity and Cytotoxicity to Cancer Cells

Volume 17, Issue 5, 2015, pp. 471-479
DOI: 10.1615/IntJMedMushrooms.v17.i5.70
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ABSTRACT

Many species of edible mushrooms are known to contain a wide array of compounds with high nutritional and medicinal values. However, these values vary widely among mushroom species because of the wide diversity of compounds with different solubilities to solvents used in extraction. We report here the comparison of antioxidant activity and cytotoxicity against cancer cells in extracts of Pleurotus ostreatus, P. sajor-caju, Agaricus campestris, and A. bisporus from 7 different solvents, including water, ethanol, ethyl acetate, acetone, chloroform, hexane, and petroleum ether. The extracts were analyzed for their antioxidant activities using the % DPPH (2,2-diphenyl-1-picrylhydrazylhydrate) scavenging activity method. Our results revealed that the water extracts exhibited the highest % DPPH scavenging activity in comparison to all other solvent extracts. The highest value was obtained from the water extract of P. sajor-caju (78.1%), and the lowest one was from the hexane extract of A. bisporus (0.8%). In general, extracts from nonpolar solvents exhibited much lower antioxidant activities than those from polar solvents. The cytotoxic effects of these extracts were evaluated using 2 cancer cell lines of larynx carcinoma (HEp-2) and breast carcinoma (MCF-7). When added into Hep-2 cells, the hexane extracts from P. ostreatus, P. sajor-caju, A. bisporus, and A. campestris yielded the highest IC50 values of 1.7 ± 1.56, 2.1 ± 2.82, 4.4 ± 1.71, and 2.2 ± 1.34 μg/mL, respectively, in comparison to all other solvent extracts. Similar IC50 values were obtained when the MCF-2 cancer cells were tested, suggesting that hexane is the preferred solvent to extract the anticancer compounds from these mushrooms. Our results also indicated that extracts from solvents with nonpolar or intermediate polarity were more potent than those with high polarity in their cytotoxicity against cancer cells, and extracts from different mushrooms by the same solvent possessed varied degrees of cytotoxicity.

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  1. Rzymski Piotr, Mleczek Mirosław, Siwulski Marek, Gąsecka Monika, Niedzielski Przemysław, The risk of high mercury accumulation in edible mushrooms cultivated on contaminated substrates, Journal of Food Composition and Analysis, 51, 2016. Crossref

  2. Ahmad Rizwan, Ahmad Niyaz, Naqvi Atta Abbas, Shehzad Adeeb, Al-Ghamdi Mastour Safer, Role of traditional Islamic and Arabic plants in cancer therapy, Journal of Traditional and Complementary Medicine, 7, 2, 2017. Crossref

  3. Poniedziałek Barbara, Mleczek Mirosław, Niedzielski Przemysław, Siwulski Marek, Gąsecka Monika, Kozak Lidia, Komosa Anna, Rzymski Piotr, Bio-enriched Pleurotus mushrooms for deficiency control and improved antioxidative protection of human platelets?, European Food Research and Technology, 243, 12, 2017. Crossref

  4. Türkekul Ibrahim, Çetin Fatma, Elmastaş Mahfuz, Fatty acid composition and antioxidant capacity of some medicinal mushrooms in Turkey, Journal of Applied Biological Chemistry, 60, 1, 2017. Crossref

  5. Lee Mi So, Kim Mi-Sook, Yoo Jae Kuk, Lee Ji Young, Ju Jae Eun, Jeong Youn Kyoung, Enhanced anticancer effects of a mixture of low-dose mushrooms and Panax ginseng root extracts in human colorectal cancer cells, Oncology Reports, 38, 3, 2017. Crossref

  6. Üstün Ramazan, Ayhan Peray, Regenerative activity of Hericium erinaceus on axonal injury model using in vitro laser microdissection technique, Neurological Research, 41, 3, 2019. Crossref

  7. Rodríguez-Seoane Paula, González-Muñoz María Jesús, Falqué Elena, Domínguez Herminia, Pressurized hot water extraction of β-glucans fromCantharellus tubaeformis, ELECTROPHORESIS, 39, 15, 2018. Crossref

  8. Rezaeian Sharareh, Pourianfar Hamid R., A comparative study on cytotoxicity and antiproliferative activities of crude extracts and fractions from Iranian wild-growing and cultivated Agaricus spp., Journal of Food Measurement and Characterization, 12, 4, 2018. Crossref

  9. Volcão Lisiane Martins, Halicki Priscila Bartolomeu, Bilibio Denise, Ramos Daniela Fernandes, Bernardi Eduardo, Da Silva Júnior Flávio Manoel Rodrigues, Biological activity of aqueous extracts of Southern Brazilian mushrooms, International Journal of Environmental Health Research, 31, 2, 2021. Crossref

  10. Suroowan Shanoo, Mahomoodally Mohamad Fawzi, Tradition Meets Innovation: Herbal Medicine as a Sustainable Source of Anticancer Agents, in Urban Health Risk and Resilience in Asian Cities, 2020. Crossref

  11. Diling Chen, Xin Yang, Chaoqun Zheng, Jian Yang, Xiaocui Tang, Jun Chen, Ou Shuai, Yizhen Xie, Extracts from Hericium erinaceus relieve inflammatory bowel disease by regulating immunity and gut microbiota, Oncotarget, 8, 49, 2017. Crossref

  12. Abd Razak Dang Lelamurni, Jamaluddin Anisah, Abd Rashid Nur Yuhasliza, Sani Nor Ajila, Abdul Manan Musaalbakri, Assessment of Cosmeceutical Potentials of Selected Mushroom Fruitbody Extracts Through Evaluation of Antioxidant, Anti-Hyaluronidase and Anti-Tyrosinase Activity, J—Multidisciplinary Scientific Journal, 3, 3, 2020. Crossref

  13. Yildirim Ayfer, Removal of the Anionic Dye Reactive Orange 16 by Chitosan/Tripolyphosphate/Mushroom, Chemical Engineering & Technology, 44, 8, 2021. Crossref

  14. Sułkowska-Ziaja Katarzyna, Fijałkowska Agata, Muszyńska Bożena, Selected Species of Medicinal/Arboreal Mushrooms as a Source of Substances with Antioxidant Properties, in Plant Antioxidants and Health, 2021. Crossref

  15. Alkin Mustafa, Söğüt Ece, Seydim Atif Can, Determination of bioactive properties of different edible mushrooms from Turkey, Journal of Food Measurement and Characterization, 15, 4, 2021. Crossref

  16. Okolo Kenneth O., Orisakwe Orish. E., In vitro antioxidants and hepatoprotective effects of Pleurotus tuber-regium on carbon tetrachloride–treated rats, Journal of Basic and Clinical Physiology and Pharmacology, 32, 2, 2021. Crossref

  17. Sułkowska-Ziaja Katarzyna, Fijałkowska Agata, Muszyńska Bożena, Selected Species of Medicinal/Arboreal Mushrooms as a Source of Substances with Antioxidant Properties, in Plant Antioxidants and Health, 2022. Crossref

  18. Volcão Lisiane Martins, Fernandes Caroline Lopes Feijó, Ribeiro Anelise Christ, Brum Rodrigo de Lima, Eslabão Chaiane Fraga, Badiale-Furlong Eliana, Ramos Daniela Fernandes, Bernardi Eduardo, da Silva Júnior Flávio Manoel Rodrigues, Bioactive extracts of Russula xerampelina and Suillus granulatus in the in vitro control of Pseudomonas aeruginosa phytopathogenic, South African Journal of Botany, 140, 2021. Crossref

  19. Wu Ziyuan, Jayachandran Muthukumaran, Cheang Wai San, Xu Baojun, Chen Lei, Black Truffle Extract Exerts Antidiabetic Effects through Inhibition of Inflammation and Lipid Metabolism Regulation, Oxidative Medicine and Cellular Longevity, 2022, 2022. Crossref

  20. Hamedi Azadeh, Bayat Maryam, Asemani Yahya, Amirghofran Zahra, A review of potential anti-cancer properties of some selected medicinal plants grown in Iran, Journal of Herbal Medicine, 33, 2022. Crossref

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