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International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.2019031652
pages 875-894

Review of Advances in Bioactive Low-Molecular-Weight Compounds, Extracts, and Biology of Phellinus sensu lato Mushrooms (Agaricomycetes) from 2011 to 2017

Yating Dong
School of Food and Biological Engineering, Jiangsu University, No. 301 Xuefu Road, Zhenjiang 212013, P.R. China
Haile Ma
School of Food and Biological Engineering, Jiangsu University, No. 301 Xuefu Road, Zhenjiang 212013, P.R. China
Cunshan Zhou
School of Food and Biological Engineering, Jiangsu University, No. 301 Xuefu Road, Zhenjiang 212013, P.R. China
Golly K. Moses
School of Food and Biological Engineering, Jiangsu University, No. 301 Xuefu Road, Zhenjiang 212013, P.R. China; Faculty of Applied Sciences and Technology, Sunyani Technical University, Sunyani, Ghana
Xiaofei Ye
School of Food and Biological Engineering, Jiangsu University, No. 301 Xuefu Road, Zhenjiang 212013, P.R. China; Department of Biosystems Engineering and Soil Science, University of Tennessee, Knoxville 37996, USA
Henan Zhang
National Engineering Research Center of Edible Fungi, Key Laboratory of Applied Mycological Resources and Utilization of Ministry of Agriculture, Shanghai Key Laboratory of Agricultural Genetics and Breeding; Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Shanghai 201403, P.R. China
Ling Sun
School of Food and Biological Engineering, Jiangsu University, No. 301 Xuefu Road, Zhenjiang 212013, P.R. China
Mohammed A.Y. Abdualrahman
Department of Food Technology, Nyala Technical College, Southern Darfur State, Nyala, Sudan


Various diseases such as cancer, hyperglycemia, and obesity negatively influence people's health and daily life. Mushroom species are miniature pharmaceutical factories producing hundreds of novel constituents with a long history of use in Oriental medicine. As a new therapy, they have attracted much attention owing to their potent therapeutic activity. Phellinus sensu lato (s.l.) is a well-known medicinal mushroom genus that has long been used in preventing ailments, including gastroenteric dysfunction, diarrhea, hemorrhage, and cancers, in Oriental countries, particularly in China, Japan, and Korea. Isolated compounds or complex extracts from Phellinus demonstrate specific bioactivity. Low-molecular-weight components, especially terpenoids, polyphenols, and other secondary metabolites, still exhibit biological activity. This review highlights the bioactive compounds from Phellinus s. l. mushrooms as being potent and having unlimited applications, especially the bioactive low-molecular-weight compounds, such as terpenoids, polyphenols, and their derivatives; also, pharmacological properties of the extracts and fractions from the fruiting bodies and the mycelia of Phellinus s. l., and the mechanism of the pharmacological activity have been discussed. This review summarized the two parts as mentioned above over a period of 7 years from 2011 to 2017.


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