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International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v14.i3.20
pages 241-256

Review of Biological and Pharmacological Activities of the Endemic Taiwanese Bitter Medicinal Mushroom, Antrodia camphorata (M. Zang et C. H. Su) Sh. H. Wu et al. (Higher Basidiomycetes)

Patrick Ying-Kit Yue
Department of Biology, Faculty of Science, Hong Kong Baptist University, Kowloon, Hong Kong SAR
Yi-Yi Wong
Department of Biology, Faculty of Science, Hong Kong Baptist University, Kowloon, Hong Kong SAR
Tony Yuk-Kit Chan
Department of Biology, Faculty of Science, Hong Kong Baptist University, Kowloon, Hong Kong SAR
Carman Ka-Man Law
Department of Biology, Faculty of Science, Hong Kong Baptist University, Kowloon, Hong Kong SAR
Yeuk-Ki Tsoi
Department of Chemistry, Faculty of Science, Hong Kong Baptist University, Kowloon, Hong Kong SAR
Kelvin Sze-Yin Leung
Department of Chemistry, Faculty of Science, Hong Kong Baptist University, Kowloon, Hong Kong SAR

ABSTRACT

Antrodia camphorata is an extremely rare fungus native to the forested regions of Taiwan. It is also a traditional Chinese medicine, and Taiwanese aborigines applied it for treating liver diseases and protecting from food and drug intoxication. Scientific studies have demonstrated that A. camphorata crude extracts and pure compounds possess a variety of beneficial functions, such as anti-hypertensive, anti-hyperlipidemic, anti-inflammatory, anti-oxidant, anti-tumor, and immuno-modulatory activities. Recent studies have shown that many of these biological and pharmacological activities can be attributed to various active constituents, including polysaccharides, terpenoids, steroids, lignans, benzoquinone derivatives, benzenoids, and maleic and succinic acid derivatives. A. camphorata has been considered as a novel phytotherapeutic agent. However, detailed mechanistic studies or even clinical trials on A. camphorata are still rare. With the help of modern analytical techniques, it is not surprising that many novel constituents are being identified or fractionated from A. camphorata mycelium and fruiting bodies. This review summarizes the latest published results from A. camphorata research, focusing on the biological and pharmacological activities of the crude extract and known constituents of A. camphorata.


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