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International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v3.i1.30
6 pages

Hypoglycemic Effects of Mycelia Produced from a Submerged Culture of Phellinus linteus (Berk. et Curt.) Teng (Aphyllophoromycetideae) in Streptozotocin-lnduced Diabetic Rats

Dong-Hyun Kim
department of Biotechnology, Taegu University, Kyungbuk 712-714, South Korea
Byung-Kun Yang
department of Biotechnology, Taegu University, Kyungbuk 712-714, South Korea
Nam-Jung Hur
department of Biotechnology, Taegu University, Kyungbuk 712-714, South Korea
Surajit Das
department of Biotechnology, Taegu University, Kyungbuk 712-714, South Korea
Jong-Won Yun
department of Biotechnology, Taegu University, Kyungbuk 712-714, South Korea
Young-Sun Choi
department of Food and Nutrition, Taegu University, Kyungbuk 712-714, South Korea
Chi-Hyun Song
Department of Biotechnology, Daegu University, Gyeongsan, Gyeongbuk, Korea

ABSTRACT

The hypoglycemic effect of Phellinus linteus (Berk. et Curt.) Teng dried mycelia was investigated in streptozotocin-induced diabetic rats. It proved to have efficacy in lowering substantially the plasma glucose and total triglyceride (TG) level in diabetic rats. A mycelial dose of 5-10% proved almost equally effective in lowering the plasma glucose level as much as 28%. It also caused a dramatic decrease in TG level at a dose of 5.0%. It lowered the TG level (56.3%) of the diabetic rats, which is even below that of normal controls. The values of glutamic pyruvic transaminase and glutamic oxaloacetic transaminase in plasma were also estimated and exhibited a substantial reduction in activity after the administration of dried mycelia. The result obtained in the present investigation indicated the efficacy of P. linteus dried mycelial powder as a therapeutic regimen for the control of diabetics.


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