Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v9.i2.40
pages 139-150

Effect of Ling Zhi or Reishi Mushroom Ganoderma lucidum (W. Curt.: Fr.) P. Karst. Mycelium on Benzo[a]prene-Induced Early Alterations of the Respiratory Epithelium in the Hypercholesterolaemic Rats

Yew Keong Choong
Phytochemistry Unit, Herbal Medicine Research Centre, Institute for Medical Research, 50588 Kuala Lumpur, Malaysia
Mohamed Mustapha Noordin
Department of Pathology and Veterinary Microbiology, Faculty of Veterinary Medicine, Universiti of Putra Malaysia, 43400 UPM, Selangor, Malaysia
Suhaila Mohamed
Department of Food Science and Management, Faculty of Food Science and Technology, Universiti of Putra Malaysia, 43400 UPM, Selangor, Malaysia
Nor Aini B. Umar
Department of Pathology, Hospital Universiti Kebangsaan Malaysia, UKM, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia
Chow Chin Tong
Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti of Putra Malaysia, 43400 UPM, Selangor, Malaysia

ABSTRACT

Many research studies indicate that fractions from the culture medium of Ganoderma lucidum mycelium (GM) have an antitumor activity through immunostimulation. There is a growing need for a short-term, cost-effective bioassay to assess the efficacy of potential antitumor agents from GM. Twenty-five Spraque-Dawley rats were divided into 5 groups according to their different feed. The positive control and negative control groups were given basal rat chew. The cholesterol (Chol) group was fed a 1% cholesterol diet, and the GM group was fed a 10% GM diet, whereby 1% Chol and 10% GM powder was added to the cholesterol plus G. lucidum mycelium (Chol+GM) group diet, respectively. All the rats were sacrificed 3 months after instillation with 13 ng of benzo[a]prene (B(a)P), except the negative control group. The lung sections were preserved for histological examination, and the glutathione S-transferase (GST) level was measured. Supplementation with GM had no significant effect on the increasing ratio of lung weight to body weight of the rats. The level of GST was significantly lower in both the Chol and positive control groups compared to the other groups. In the Chol+GM group, no significant lesions were observed in the lungs. No significant gross pathological changes were observed in the lungs of the negative control, GM, or Chol+GM groups. However, small whitish nodules were observed in the lungs of 3 rats from the positive control group and on both lungs in all rats from the Chol group. The study reported herein showed that GM is an effective treatment in inhibiting B(a)P-induced carcinogenesis in rats.


Articles with similar content:

The Effects of a Powder of the Fruiting Body of Commercial Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (W.Curt.:Fr.) P.Karts.,] on Hypercholesterolemic Rat Skin, Applied With a Topical Application of Benzo(a)pyrene
International Journal of Medicinal Mushrooms, Vol.12, 2010, issue 4
Nor Aini B. Umar, Sulaila Mohamad, Tong Chow Chin, Choong Yew Keong, Noordin M. Mustapha
Radioprotection of Swiss albino mice by Prunus avium with special reference to hematopoietic system
Journal of Environmental Pathology, Toxicology and Oncology, Vol.30, 2011, issue 1
Smita Singh, Ekta Meghnani, Preeti Srivastava, Rashmi Sisodia, chaturbhuj Mundotiya
Curative Effect of Amorphophallus campanulatus (Roxb.) Blume. Tuber On N-Nitrosodiethylamine- Induced Hepatocellular Carcinoma in Rats
Journal of Environmental Pathology, Toxicology and Oncology, Vol.33, 2014, issue 3
Santhibhavan Prabhakaran Prabha, Anand Nitha, Puthuparampil Nazarudeen Ansil, Mukalel Sankunni Latha
Protective Role of Curcumin and Flunixin Against Acetic Acid−Induced Inflammatory Bowel Disease via Modulating Inflammatory Mediators and Cytokine Profile in Rats
Journal of Environmental Pathology, Toxicology and Oncology, Vol.34, 2015, issue 4
G BOOBALAN, Matukumalli Usha Rani, C.S.V. Satish Kumar, Alla Gopala Reddy, Rasakatla Dileep, Matham Vijay Kumar
Carotenoid Lutein Protects the Kidney against Cisplatin-Induced Acute Renal Failure
Journal of Environmental Pathology, Toxicology and Oncology, Vol.32, 2013, issue 1
Ramadasan Kuttan, Edakkadath Raghavan Sindhu