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International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v1.i3.30
pages 217-222

Pharmacology and Clinical Application of the Spores of Ganoderma lucidum (Curt.: Fr.) P. Karst. and Mycelium of Ganoderma capense (Lloyd) Teng. (Aphyllophromycilideae)

Geng Tao Liu
Department of Pharmacology, Institute of Materia Medica Chinese Academy of Medical Sciences; and Peking Union Medical College, Beijing 100050, China

ABSTRACT

Many studies on the fruiting bodies of Ganoderma lucidum (Curt.: Fr.) P. Karst. and G. japonicum (Fr.) Lloyd have been carried out. The study of G. lucidum spores and G. capense (Lloyd) Teng mycelium produced by submerged fermentation is rare. This article mainly reviews the results of our studies on the pharmacology and clinical uses of G. lucidum spores and G. capense mycelium. In general, the alcohol-water-soluble portion of both Ganoderma materials given by injection has a sedative effect on the central nervous system, promotes circulation, and modulates immune function and antiallergic inflammation in animals. The alcohol-ether extract of both Ganoderma samples showed protective action against experimental liver damage in mice. The injections made from the alcohol-water-soluble fraction of G. lucidum spores and G. capense mycelium have been used in the treatment of several kinds of neuromuscular diseases such as dermatomyositis, scleroderma, and alopecia. Some therapeutic effects were observed.


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