Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v17.i12.40
pages 1145-1149

Antiproliferative Activity of Some Higher Mushrooms from Hungary against Human Cancer Cell Lines

Attila Vanyolos
University of Szeged, Department of Pharmacognosy 6720 Szeged Eötvös u. 6., Hungary
Bernadett Kovacs
Department of Pharmacognosy, University of Szeged, Szeged, Hungary
Noemi Bozsity
Department of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Hungary
Istvan Zupko
Department of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Hungary
Judit Hohmann
Department of Pharmacognosy, University of Szeged, Szeged, Hungary; Interdisciplinary Centre for Natural Products, University of Szeged, Szeged, Hungary

ABSTRACT

In the present work, aqueous and organic extracts of 16 Basidiomycetes mushrooms and 1 Ascomycetes mushroom were investigated in vitro for their antiproliferative activity against HeLa (cervix epithelial adenocarcinoma), A431 (skin epidermoid carcinoma), A2780 (ovarian carcinoma), and MCF7 (breast epithelial adenocarcinoma) cells, using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. A total of 68 n-hexane, chloroform, 50% methanol, and water extracts of selected species were screened for their potential cell growth inhibitory activity. Our experiments revealed that 7 of 17 species demonstrated notable antiproliferative activity (at least 50% inhibition of cell proliferation) against one or more cell lines. Kuehneromyces mutabilis, Lactarius quietus, and Lentinellus cochleatus, which exerted the highest activity on cancer cells, are considered valuable species in the perspective of further mycochemical studies.