Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v17.i10.70
pages 977-985

Statistical Optimization of the Content Composition Precursors Using Response Surface Methodology to Enhance Agaricoglyceride A Production from the Shaggy Ink Cap Medicinal Mushroom, Coprinus comatus (Higher Basidiomycetes) Mycelia

Wei Wang
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, P. R. China
Zhibiao Di
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, P. R. China
Ruiguo Li
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, P. R. China
Jingzhen Tian
School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, P. R. China

ABSTRACT

Coprinus comatus, a novel cultivated edible mushroom, has a various of pharmacological effects due to its many active components. In this study, agaricoglycerides, a new class of fungal secondary metabolites that have strong activity against neurolysin, were isolated from C. comatus mycelia. Simultaneously, a 3-level Box−Behnken factorial design was used, combined with response surface methodology, to optimize the precursor composition of agaricoglycerides for the production of agaricoglyceride A. The model estimated that a maximal yield of agaricoglyceride A (20.105 mg/L) could be obtained when the concentrations of 4-hydroxybenzoic acid, glycerol, and methanol (MeOH) were set at 75 mg/L, 0.75 mL/L, and 0.75 mL/L, respectively. The verified experiments showed that the model was significantly consistent with the model prediction. These results showed that appropriately adding the precursors could increase the production of agaricoglyceride A.


Articles with similar content:

Enhanced Production of Medicinal Polysaccharide by Submerged Fermentation of Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidium (W.Curt.:Fr.) P. Karst. Using Statistical and Evolutionary Optimization Methods
International Journal of Medicinal Mushrooms, Vol.13, 2011, issue 5
Gurunathan Baskar, Shree Rajesh K. Lakshmi Jai Sathya
Optimization of Submerged Cultivation Conditions for Extra- and Intracellular Polysaccharide Production by Medicinal Ling Zhi or Reishi Mushroom Ganoderma lucidum (W. Curt.: Fr.) P. Karst. (Aphyllophoromycetideae)
International Journal of Medicinal Mushrooms, Vol.10, 2008, issue 4
Jasmina Simonic, Jelena Vukojević, Ilija Brceski, Sonja Duletic-Lausevic, Mirjana Stajic, Jasmina Glamoclija
Antibacterial Activity of Some Indian Mushrooms
International Journal of Medicinal Mushrooms, Vol.2, 2000, issue 2
Sangita Dighe, A. D. Agate
Optimization of Melanin Extraction from the Wood Ear Medicinal Mushroom, Auricularia auricula-judae (Agaricomycetes), by Response Surface Methodology and Its Antioxidant Activities In Vitro
International Journal of Medicinal Mushrooms, Vol.20, 2018, issue 11
Jiao-Jiao Tian, Jie-Chi Zhang, Xiao-Dong Dai, Yin-Peng Ma, Bing Han, Jia-Ning Liu, Xi-Jun Chen, Qing-Fang Ma, Zeng-Hua Han, Hui Wang, Xiang-Hui Kong, Yi-Hong Bao, Pi-Qi Zhang
Screening for Antimicrobial Activity of Wood Rotting Higher Basidiomycetes Mushrooms from Uruguay against Phytopathogens
International Journal of Medicinal Mushrooms, Vol.18, 2016, issue 3
Alvaro Vázquez, María Pía Cerdeiras, Gianna Cecchetto, Stephanie Barneche, Gabriela Jorcin, Silvana Alborés