Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v13.i2.20
pages 109-113

Effect of Immunomodulating and Antiviral Agent of Medicinal Mushrooms (Immune Assist 24/7TM) on CD4+ T-Lymphocyte Counts of HIV-Infected Patients

Gideon Adotey
Science Laboratory Department, Accra Polytechnic, Accra, Ghana
Abraham Quarcoo
Science Laboratory Department, Accra Polytechnic, Accra, Ghana
John Holliday
Aloha Medicinals, Inc. 2300 Arrowhead Dr., Carson City, NV 89706, USA
Solomon Fofie
Sunyani Regional Hospital, Sunyani, Brong-Ahafo, Ghana
Braimah Saaka
Sunyani Regional Hospital, Sunyani, Brong-Ahafo, Ghana

ABSTRACT

Immune enhancement through the use of natural products is a potentially valuable therapeutic modality in HIV-infected people, especially those who are not good candidates for aggressive ARV therapy. One such immune enhancement, a medicinal mushroom product from the United States, is Immune Assist 24/7TM. In this study the effect of Immune Assist 24/7TM., which is a naturally derived immune-modulating and antiviral agent, on CD4+ T-lymphocyte counts was evaluated in 8 HIV-infected patients at the Sunyani Regional Hospital (Ghana). The subjects were administered three tablets of 800 mg Immune Assist 24/7TM. once daily (2.4 g/day) and peripheral blood samples were drawn at baseline, day 30, and day 60, and the CD4+ count measured. The study revealed that Immune Assist 24/7TM., used as a sole therapeutic agent without additional ARV drugs, significantly increased CD4+ T-lymphocyte populations in all of the patients. In one patient, the CD4+ T-lymphocyte count went from 4 at the baseline, to 170 cells in 60 days, representing an increase of more than 4000%. In another patient, the CD4+ count went from 88 to 470 cells within the same period. Even in the patients with the highest CD4+ counts of around 800, there was a significant elevation in the CD4+ count noted. This study did not deal with the effect of Immune Assist 24/7TM. on other immune parameters such as CD3+ T-lymphocyte count, natural killer cells count, or viral load among HIV-infected patients. These initial results are promising, and indicate the potential value of further evaluating the effects of Immune Assist 24/7TM. on other immune parameters and viral load among HIV patients, administered either as a sole therapeutic agent, as an adjuvant with standard ARV therapy, or in comparison with standard ARV therapy alone.


Articles with similar content:

The Clinical Use of Mushrooms in Oncology
International Journal of Medicinal Mushrooms, Vol.7, 2005, issue 3
Steven Kh. Aung
Perioperative Immunosuppression in Cancer Patients
Journal of Environmental Pathology, Toxicology and Oncology, Vol.22, 2003, issue 2
Ricardo Vallejo, E. Daniela Hord, Steven A. Barna, Juan Santiago-Palma, Shihab Ahmed
Immunotherapy of Colon Cancer Using Chimeric mAb 31.1
Critical Reviews™ in Immunology, Vol.18, 1998, issue 1-2
Tommy Wang, Myron Arlen, Al Tsang
Randomized Clinical Trial for the Evaluation of Immune Modulation by Yogurt Enriched with β-Glucans from Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), in Children from Medellin, Colombia
International Journal of Medicinal Mushrooms, Vol.20, 2018, issue 8
Edwin A. Higuita, Andrea M. Cano, Sandra Lorena Duque Henao, Sergio A. Urrego
A Randomized, Placebo-Controlled, Multicenter Study of Ganoderma lucidum (W.Curt.:Fr.) Lloyd (Aphyllophoromycetideae) Polysaccharides (Ganopoly®) in Patients with Advanced Lung Cancer
International Journal of Medicinal Mushrooms, Vol.5, 2003, issue 4
Guoliang Chen, Jingxian Ye, Yihuai Gao, Shufeng Zhou, Xihu Dai