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International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v14.i6.50
pages 575-580

Assessment of Anti-inflammatory, Lipid Peroxidation and Acute Toxicity of Extracts Obtained From Wild Higher Basidiomycetes Mushrooms Collected From Akure (Southwest Nigeria)

Victor O. Oyetayo
Department of Microbiology, Federal University of Technology, P.M.B. 704, Akure, Nigeria; Instituto de Quimica, Universidad Nacional Autonoma de Mexico, Circuito Exterior, Ciudad Universitaria, 04510 Coyoacan, Mexico, DF, Mexico
Antonio Nieto-Camacho
Instituto de Quimica, Universidad Nacional Autonoma de Mexico, Circuito Exterior, Ciudad Universitaria, 04510 Coyoacan, Mexico, DF, Mexico
Baldomero Esquivel Rodriguez
Instituto de Quimica, Universidad Nacional Autonoma de Mexico, Circuito Exterior, Ciudad Universitaria, 04510 Coyoacan, Mexico, DF, Mexico
Manuel Jimenez
Instituto de Quimica, Universidad Nacional Autonoma de Mexico, Circuito Exterior, Ciudad Universitaria, 04510 Coyoacan, Mexico, DF, Mexico

ABSTRACT

Ethanolic extracts of three wild medicinal mushrooms, namely Lenzites betulina (LET), Trametes versicolor (TET), and Coriolopsis polyzona (CET), collected from Akure, southwest Nigeria, were assessed for their lipid peroxidation, anti-inflammatory, and acute toxicity effects. The inhibition of the formation of thiobarbituric acid reactive species (TBARS) by extracts was concentration dependent and ranged from 86.99% to 92.18% at 1000 µg/ mL. The IC50 of the extracts was also in the range of 222.81 µg/mL to 737.13 µg/mL. The anti-inflammatory effect measured by inhibition of mice ear edema was higher and significantly different (P ≤ 0.05) than the control. The acute toxicity test also revealed tolerance to the three ethanolic extracts by Artemia salina at concentrations of 10 µg/mL to 1000 µg/mL, except for ethanolic extracts of LET and TET, which exhibited toxicity against this invertebrate at 1000 µg/mL. This research has shown that ethanolic extracts of these three macrofungi could be good sources of safe and effective antioxidant and antinflammatory agents for biopharmaceutical exploitation.


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