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International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v4.i2.60
6 pages

Anticarcinogenic Activity of Two Species of Phansomba, Phellinus merrillii (Murr.) Ryv . and Ph. fastuosus (Lev.) Ryv., on SiHa Cell Lines

Ramesh R. Bhonde
National Centre for Cell Science, Pune University Campus, Pune 411 007, India
Prasad Y. Lamrood
Department of Botany, Ahmednagar College (affiliated with Savitribai Phule Pune University), Ahmednagar, Maharashtra, India
Jitendra G. Vaidya
Department of Botany, University of Pune, Ganeshkhind Road, Pune-411 007, Maharashtra, India

ABSTRACT

Preliminary experiments to check anticarcinogenic activity using human cervical carcinoma cells (SiHa cells) were carried out with two species of Phansomba, Phellinus merrillii (Murr.) Ryv. and Ph. fastuosus (Lev.) Ryv. The study suggests that the hot and cold water extracts as well as hot and cold 50% ethanol extracts of these species show anticarcinogenic activity. Our studies revealed that cold and hot water extracts of Ph. merrillii, and cold and hot ethanol extracts of both species have high cytotoxic effect on SiHa cells. Ph. merrillii cold and hot water extracts demonstrated higher cytotoxic effect than those from Ph. fastuosus, while cold and hot ethanol extracts from both species entirely inhibited SiHa cell growth at a concentration of 500 mg.


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