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International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v11.i4.30
pages 365-373

Anti-inflammatory and Free Radical Scavenging Activities of Polysaccharide−Protein Complex Isolated from Phellinus rimosus (Berk.) Pilát (Aphyllophoromycetideae)

Kainoor K. Janardhanan
Department of Microbiology, Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India
Chakrapully R. Meera
Amala Cancer Research Centre, Amala Nagar, Thrissur-680 555
Balan Nitha
Amala Cancer Research Centre, Amala Nagar, Thrissur-680 555
Ram A. Vishwakarma
Medical Chemistry Group, Nicholas Piramal Research Centre, Nirolon Complex, Goregaon (E), Mumbai-400 063

ABSTRACT

Phellinus rimosus (Berk.) Pilát is a polypore mushroom found growing on jackfruit trees (Atrocarpus heterophyllus) in Kerala, India. Our previous investigations have demonstrated a variety of biological activities of this species. In this article, we report the anti-inflammatory and free radical scavenging activities of a polysaccharide−protein complex (PPC-Pr) isolated from the fruiting bodies of Ph. rimosus. The PPC-Pr was isolated from the hot water extract by solvent precipitation, depro-teinization, dialysis, and freeze drying. The anti-inflammatory activity of PPC-Pr was determined by carrageenan- and dextran-induced acute and formalin-induced chronic inflammatory models. The free radical scavenging activity of PPC-Pr was determined by evaluating superoxide radical, hydroxyl radical, nitric oxide, and 1,1-diphenyl 2-picryl hydrazyl (DPPH) radical scavenging activities; inhibition of lipid peroxidation; and ferric reducing antioxidant power (FRAP). The PPC-Pr showed 75.24% and 88.28% inhibition of acute and 65.74% inhibition of chronic inflammation when treated at a concentration of 50 mg/kg body weight. PPC-Pr also showed significant hydroxyl radical scavenging activity (IC50: 430.0 ± 5.0) and lipid peroxidation-inhibiting activity (IC50: 253.3 ± 7.6). The results thus reveal that PPC-Pr possesses profound anti-inflammatory and free radical scavenging activities. The findings suggest the potential therapeutic use of the polysaccharide−protein complex (PPC-Pr) isolated from Ph. rimosus.


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