Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v18.i4.30
pages 301-311

Effects of Black Hoof Medicinal Mushroom, Phellinus linteus (Agaricomycetes), Polysaccharide Extract in Streptozotocin-Induced Diabetic Rats

Mustafa Yamac
Eskisehir Osmangazi University, Faculty of Science and Arts, Department of Biology, Eskisehir, Turkey
Melih Zeytinoglu
Emeritus, Anadolu University, Science Faculty, Department of Biology, Eskisehir, Turkey
Hakan Senturk
Eskisehir Osmangazi University, Science and Arts Faculty, Department of Biology, Eskisehir, Turkey
Kazim Kartkaya
Eskisehir Osmangazi University, Graduate School of Medical Sciences, Eskisehir, Turkey
Gungor Kanbak
Eskisehir Osmangazi University, Medicine Faculty, Department of Biochemistry, Eskisehir, Turkey
Gokhan Bayramoglu
Artvin Coruh University, Faculty of Health Sciences, Department of Occupational Health and Safety, Artvin, Turkey
Aysegul Oglakci
Eskisehir Osmangazi University, Graduate School of Medical Sciences, Eskisehir, Turkey
Leonardus Johannes Lambertus Donatus Van Griensven
Plant Research International, Wageningen University and Research Centre, Wageningen, the Netherlands

ABSTRACT

In this article we report the healing effects of a Phellinus linteus fruiting body hot water extract (PLE) in streptozotocin (STZ)−induced diabetic rats. PLE was given before and after STZ. The preprotective, protective, and postprotective effects of PLE on STZ-induced oxidative stress were studied using biochemical (caspase 3 activity, cytosolic-to-lysosomal ratio of cathepsin B and L, DNA fragmentation levels), ordinary histological and immuno-histochemical investigation parameters. Following oral administration of PLE after STZ application, the serum glucose concentration significantly decreased up to 41.13% compared with the control group (P < 0.05). The hypoglycemic potential of the PLE was further supported by an increase of insulin secretion in the islets of Langerhans. In addition, the number of cells in Langerhans islets increased by 45.89% when PLE was given after STZ application. On the other hand, the use of PLE before oxidative stress could not prevent the onset of diabetes. This is, to our knowledge, the first study of the effect of application time of orally administered Ph. Linteus hot water extract on STZ-induced diabetes.


Articles with similar content:

Black Hoof Medicinal Mushroom Phellinus linteus (Agaricomycetes) Extracts Protect Against Radiation-Induced Hematopoietic Abnormality in Mice
International Journal of Medicinal Mushrooms, Vol.18, 2016, issue 5
Chih-Chung Su, Shu-Ming Huang, Miao-Lin Hu, Jen-Yin Chen, Chin-Chu Chen
Characterization of the Effects of the Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), on Severe Gestational Diabetes Mellitus in Rats
International Journal of Medicinal Mushrooms, Vol.19, 2017, issue 11
Erika Leão Ajala Caetano, Leticia Favara Laurino, Angela Faustino Jozala, Carolina Alves dos Santos, Marli Gerenutti, Sara Rosicler Vieira Spim, Lucas Silva Rodrigues, Denise Grotto, Bianca Carvalho Gentil, Bianca Hessel Maschio
Hypoglycemic Effects of Mycelia Produced from a Submerged Culture of Phellinus linteus (Berk. et Curt.) Teng (Aphyllophoromycetideae) in Streptozotocin-lnduced Diabetic Rats
International Journal of Medicinal Mushrooms, Vol.3, 2001, issue 1
Dong-Hyun Kim, Young-Sun Choi, Nam-Jung Hur, Chi-Hyun Song, Jong-Won Yun, Surajit Das, Byung-Kun Yang
Hypoglycemic and Hypolipidemic Effects of the Cracked-Cap Medicinal Mushroom Phellinus rimosus (Higher Basidiomycetes) in Streptozotocin-Induced Diabetic Rats
International Journal of Medicinal Mushrooms, Vol.17, 2015, issue 6
Thekkuttuparambil Ananthanarayanan Ajith, Kainoor K. Janardhanan, Kuttikkadan A. Rony
The Effects of the King Oyster Mushroom Pleurotus eryngii (Higher Basidiomycetes) on Glycemic Control in Alloxan-Induced Diabetic Mice
International Journal of Medicinal Mushrooms, Vol.16, 2014, issue 3
Huan Zhan, Ya-li Lei, Jian-Ping Li