Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
International Journal of Medicinal Mushrooms
IF: 1.423 5-Year IF: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN Print: 1521-9437
ISSN Online: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v15.i5.60
pages 487-495

Optimization of Submerged Fermentation Conditions for Lovastatin Production by the Culinary-Medicinal Oyster Mushroom, Pleurotus ostreatus (Higher Basidiomycetes)

Burcu Atli
Eskisehir Osmangazi University, Graduate School of Natural and Applied Sciences
Mustafa Yamac
Eskisehir Osmangazi University, Faculty of Science and Arts, Department of Biology, Eskisehir, Turkey
Zeki Yildiz
Department of Statistics, Faculty of Science and Arts, Eskisehir Osmangazi University, Eskisehir, Turkey


Statistical experimental designs were used to optimize lovastatin production by culinary-medicinal oyster mushroom Pleurotus ostreatus OBCC 1031 under submerged fermentation. The Plackett-Burman design was used to determine effective culture parameters, glucose, lactose, maltose, glycerol, peptone, yeast extract, NH4SO2, NaCl, thiamine, and agitation speed. Statistical analyses of data from the Plackett-Burman design show that glucose, yeast extract, and agitation speed are significant parameters. The interactive effects of these culture parameters on lovastatin production by P. ostreatus OBCC 1031 were further studied by a Box-Behnken design. Maximum lovastatin production (114.82 mg/L) was reached after 6 days of fermentation in optimized culture conditions (30 g/L glucose, 10 g/L yeast extract, 200 rpm, 28°C, and pH 6). This amount was found to be 50 times higher than that produced under unoptimized conditions in submerged fermentation by P. ostreatus.

Articles with similar content:

Production of Extracellular Polysaccharides by the Medicinal Mushroom Trametes trogii (Higher Basidiomycetes) in Stirred-Tank and Airlift Reactors
International Journal of Medicinal Mushrooms, Vol.15, 2013, issue 2
Wenye Zhang, Chunping Xu, Lujing Geng
The Influence of Cultivation Conditions on Mycelial Growth and Exopolysaccharide Production of Culinary-Medicinal Mushroom Pleurotus citrinopileatus Singer (Agaricomycetideae)
International Journal of Medicinal Mushrooms, Vol.10, 2008, issue 3
Chiu-Yeh Wu
Cultivation of Medicinal Mushrooms on Spruce Sawdust Fermented with a Liquid Digestate from Biogas Stations
International Journal of Medicinal Mushrooms, Vol.21, 2019, issue 3
Ivan Jablonský, Adam Brezáni, Katerina Svobodova, Pavel Tlustoš
Nutritional Requirements for Mycelial Growth of Milk-White Toothed Mushroom, Irpex lacteus (Agaricomycetes), in Submerged Culture
International Journal of Medicinal Mushrooms, Vol.19, 2017, issue 9
Xiaoming Dong, Xinhua Song, Caihong Dong
Optimization of the Production of Extracellular Polysaccharide from the Shiitake Medicinal Mushroom Lentinus edodes (Agaricomycetes) Using Mutation and a Genetic Algorithm−Coupled Artificial Neural Network (GA-ANN)
International Journal of Medicinal Mushrooms, Vol.18, 2016, issue 7
Agbaje Lateef, Adeyemi Ojutalayo Adeeyo, Evariste Bosco Gueguim-Kana