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Critical Reviews™ in Physical and Rehabilitation Medicine

Published 4 issues per year

ISSN Print: 0896-2960

ISSN Online: 2162-6553

SJR: 0.141 SNIP: 0.129 CiteScore™:: 0.6 H-Index: 18

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Central Neuropathic Pain in Spinal Cord Injury

Volume 25, Issue 3-4, 2013, pp. 159-172
DOI: 10.1615/CritRevPhysRehabilMed.2013007944
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ABSTRACT

Spinal cord injury (SCI) is a devastating medical condition affecting 1.2 million people in the United States. Central neuropathic pain is one of the most common medical complications of SCI. Current treatment options include opioids, antiepileptic agents such as gabapentin, antispastic agents such as baclofen or tizanidine, and tricyclic acid. Other options include complementary, nonpharmacological treatment such as exercise or acupuncture, interventional treatments, and psychological approaches. Although these treatment options exist, central neuropathic pain in patients with SCI is still extremely difficult to treat because of its complexity. To develop and provide more effective treatment options to these patients, proper assessment of and classification tools for central neuropathic pain, as well as a better understanding of the pathophysiology, are needed. A combination of approaches, from standard general pain assessments to medically specific questions unique to SCI pathophysiology, is essential for this population.

A multidisciplinary approach to patient care, in addition with a better understanding of pathophysiology and diagnosis, will lead to improved management and treatment of patients with SCI displaying central neuropathic pain. Here we summarize the most recent classification tools, pathophysiology, and current treatment options for patients with SCI with central neuropathic pain.

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  10. Lee Hye-Lan, Yeum Chung-Eun, Lee HyeYeong, Oh Jinsoo, Kim Jong-Tae, Lee Won-Jin, Ha Yoon, Yang Young-Il, Kim Keung-Nyun, Peripheral Nerve-Derived Stem Cell Spheroids Induce Functional Recovery and Repair after Spinal Cord Injury in Rodents, International Journal of Molecular Sciences, 22, 8, 2021. Crossref

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