Publicado 4 números por año
ISSN Imprimir: 0731-8898
ISSN En Línea: 2162-6537
Indexed in
Efficacy of Curcumin in Ameliorating Aluminum- Induced Neurotoxicity
SINOPSIS
Background−The present study evaluated the efficacy of curcumin as a nutritional supplement in
preventing aluminum-induced neurotoxicity in rats.
Methods−The rats were segregated into four groups, which included normal controls and aluminum-treated, curcumin-
treated, and aluminum- and curcumin-treated animals.
Results−Eight weeks of aluminum treatment resulted in a significant increase in the levels of lipid peroxidation
(LPO) and reactive oxygen species (ROS) in both cerebellum and cerebrum as compared to normal animals. In contrast, the activities of glutathione-S-transferase (GST), glutathione reductase (GR), superoxide dismutase (SOD), and reduced glutathione (GSH) levels were found to be significantly decreased following aluminum treatment. Furthermore, aluminum resulted in anxiety in rats as determined with the elevated plus maze test. In addition, an appreciable decrease was noticed in both muscular and locomotor activity of aluminum-treated animals, as determined by rotarod and actophotometer tests, respectively. However, in aluminum-treated animals that also received curcumin supplements, the already raised levels of LPO and ROS returned to near normal limits in the cerebrum. Moreover, curcumin treatment of the aluminum-treated animals also resulted in a significant improvement in the levels of GSH
and enzyme activities of GST in both the cerebrum and cerebellum. Also, improvement was observed in the behavior
of aluminum-treated animals upon curcumin supplementation.
Conclusion−The present study suggests that curcumin may act as a neuroprotectant against aluminum-induced
neurodegenerative and behavioral disorders, but further investigations are needed to understand the exact mechanism
of neuroprotection.
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Ikram Muhammad Faisal, Farhat Syeda Mehpara, Mahboob Aamra, Baig Saeeda, Yaqinuddin Ahmed, Ahmed Touqeer, Expression of DnMTs and MBDs in AlCl3-Induced Neurotoxicity Mouse Model, Biological Trace Element Research, 199, 9, 2021. Crossref
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