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Journal of Environmental Pathology, Toxicology and Oncology

Publicado 4 números por año

ISSN Imprimir: 0731-8898

ISSN En Línea: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Chemopreventive Effect of Cardamom (Elettaria cardamomum L.) Against Benzo(α)Pyrene-Induced Forestomach Papillomagenesis in Swiss Albino Mice

Volumen 34, Edición 2, 2015, pp. 95-104
DOI: 10.1615/JEnvironPatholToxicolOncol.2015010838
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Samir Qiblawi
Department of Histology, College of Medicine, University of Hail, Hail, Saudi Arabia
Sasikumar Dhanarasu
Department of Biochemistry, College of Medicine, University of Hail, Saudi Arabia
Mo'ez Al-Islam Faris
Department of Clinical Nutrition, College of Applied Medical Sciences, University of Hail, Hail, Saudi Arabia; Depatment of Clinical Nutrition and Dietetics, College of Health Sciences, University of Sharjah, United Arab Emirates

SINOPSIS

Prevention of cancer through dietary intervention has recently gained significant recognition. Cardamom (Elettaria cardamomum), a dietary phytoproduct, is a popular spice that is regularly used as a flavoring agent in various cuisines, and is much valued for its medicinal properties. In the present study, the cancer chemopreventive potential of cardamom was investigated against benzo(α)pyrene [B(α)P]−induced forestomach papillomagenesis in mice. Results showed that treatment with cardamom [(B(α)P + cardamom] reduced tumor incidence and multiplicity significantly (P<0.001) by 41.67% and 74.55%, respectively, compared to that of the B(α)P control group. Biochemical assays revealed a significant enhancement in the hepatic activities of glutathione-S-transferases (P<0.01), superoxide dismutase (P<0.01), glutathione peroxidase (P<0.001), and catalase (P<0.001) in mice treated with cardamom compared with the control. Furthermore, the nonenzymatic antioxidant glutathione was significantly (P<0.001) increased in the cardamom-treated group, whereas the lipid peroxidation level along with lactate dehydrogenase activity exhibited a significant (P<0.01) reduction with cardamom treatment compared to the control. These results suggest that cardamom has the potential to become a pivotal chemopreventive agent against forestomach cancer.

PALABRAS CLAVE: cardamom (Elettaria cardamomum), dietary chemoprevention, antioxidant enzymes, carcinogendetoxifying enzymes, forestomach papillomagenesis
CITADO POR

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  2. Goyal Sameer, Sharma Charu, Mahajan Umesh, Patil Chandragouda, Agrawal Yogeeta, Kumari Santosh, Arya Dharamvir, Ojha Shreesh, Protective Effects of Cardamom in Isoproterenol-Induced Myocardial Infarction in Rats, International Journal of Molecular Sciences, 16, 11, 2015. Crossref

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  4. Kandikattu Hemanth Kumar, Rachitha P., Jayashree G.V., Krupashree K., Sukhith M., Majid Abdul, Amruta Narayanappa, Khanum Farhath, Anti-inflammatory and anti-oxidant effects of Cardamom ( Elettaria repens (Sonn.) Baill) and its phytochemical analysis by 4D GCXGC TOF-MS, Biomedicine & Pharmacotherapy, 91, 2017. Crossref

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  7. Kunnumakkara Ajaikumar B., Sailo Bethsebie L., Banik Kishore, Harsha Choudhary, Prasad Sahdeo, Gupta Subash Chandra, Bharti Alok Chandra, Aggarwal Bharat B., Chronic diseases, inflammation, and spices: how are they linked?, Journal of Translational Medicine, 16, 1, 2018. Crossref

  8. Ahmad Rumana, Khan Mohsin A., Srivastava A.N., Gupta Anamika, Srivastava Aditi, Jafri Tanvir R., Siddiqui Zainab, Chaubey Sunaina, Khan Tahmeena, Srivastava Arvind K., Anticancer Potential of Dietary Natural Products: A Comprehensive Review, Anti-Cancer Agents in Medicinal Chemistry, 20, 2, 2020. Crossref

  9. SOUZA Caroline Cardoso de, OLIVEIRA Catarina Amorim, PIRES Jéssica Fontinelly, PIMENTEL Tatiana Colombo, RAICES Renata Santana Lorenzo, NOGUEIRA Luciana Cardoso, Physicochemical characteristics and sensory acceptance of a mixed beverage based on organic apple juice and cardamom tea (Elettaria cardamomum) with allegation of functional properties, Food Science and Technology, 40, suppl 2, 2020. Crossref

  10. Kunnumakkara Ajaikumar B., Rana Varsha, Parama Dey, Banik Kishore, Girisa Sosmitha, Henamayee Sahu, Thakur Krishan Kumar, Dutta Uma, Garodia Prachi, Gupta Subash C., Aggarwal Bharat B., COVID-19, cytokines, inflammation, and spices: How are they related?, Life Sciences, 284, 2021. Crossref

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