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Journal of Environmental Pathology, Toxicology and Oncology

Publicado 4 números por año

ISSN Imprimir: 0731-8898

ISSN En Línea: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Heavy Metal−Induced Systemic Dysfunction Attenuated by Tannic Acid

Volumen 35, Edición 2, 2016, pp. 109-120
DOI: 10.1615/JEnvironPatholToxicolOncol.2016014527
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SINOPSIS

Lead toxicity is a major public health concern. This study was designed to investigate the effects of oral administration of tannic acid (TA) on lead acetate (LA)−induced oxidative stress in rat liver and kidney. Rats were treated with 50 mg/kg body weight of TA against LA-induced oxidative stress 3 times/week for 2 weeks. At a rate of 50 mg/kg of body weight, LA was given intraperitoneally 3 times/week for 2 weeks. Results show significantly elevated levels of oxidative stress markers observed in LA-treated rats, whereas significant depletion in the activity of nonenzymatic and enzymatic antioxidants as well as histological changes were observed in LA-treated rat liver and kidney. TA treatment significantly attenuated the altered levels of oxidative stress biomarkers for nonenzymatic and enzymatic antioxidants. We demonstrated that TA exhibits potent antioxidant and protected against oxidative damage in rat liver and kidney induced by LA treatment. These findings were further supported by histopathological findings in liver and kidney showing that TA protected tissue from the deleterious effects of LA treatment. These outcomes suggest that the consumption of TA may confer a protective effect against lead intoxication through its antioxidative effect.

PALABRAS CLAVE: lead, liver, kidney, rats, toxicity, antioxidant
CITADO POR
  1. Vitlov Uljević Marija, Bočina Ivana, Restović Ivana, Kunac Nenad, Mašek Tomislav, Kretzschmar Genia, Grobe Maximilian, Šarić Mia, Vukojević Katarina, Saraga-Babić Mirna, Filipović Natalija, Reabsorption in the proximal tubuli—ultrastructural evidence for a novel aspect of renal VEGF trafficking, Cell and Tissue Research, 374, 1, 2018. Crossref

  2. Alshahrani Saeed, Tripathi Pankaj, Ashafaq Mohammad, Sultan Muhammad H., Moni Sivakumar Sivagurunathan, Tripathi Rina, Siddiqui Abdul Hakeem, Rashid Hina, Malhan Ali M., Role of renin blocker (Aliskiren) on Cisplatin induced-nephrotoxicity in rats, Toxin Reviews, 41, 1, 2022. Crossref

  3. Dar Mohd. Shafi, Mittal Deepak Kumar, Tabasum Shazia, Antioxidant, Anti-inflammatory and hepatoprotective activities of Persicaria maculosa (linn.) and its active principle i.e tannic acid against Carbon tetrachloride induced oxidative stress and hepatotoxicity in wistar rats, IP International Journal of Forensic Medicine and Toxicological Sciences, 7, 1, 2022. Crossref

  4. Li Ning, Wen Liuding, Yu Zengli, Li Tiange, Wang Tianlin, Qiao Mingwu, Song Lianjun, Huang Xianqing, Effects of folic acid on oxidative damage of kidney in lead-exposed rats, Frontiers in Nutrition, 9, 2022. Crossref

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