Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
Journal of Environmental Pathology, Toxicology and Oncology
Factor de Impacto: 1.625 Factor de Impacto de 5 años: 1.63 SJR: 0.402 SNIP: 0.613 CiteScore™: 2.3

ISSN Imprimir: 0731-8898
ISSN En Línea: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.2017020182
pages 283-291

Oral Insulin: Current Status, Challenges, and Future Perspectives

Dinesh Kumar Chellappan
Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia 57000
Yap Yenese
School of Health Sciences, International Medical University, Kuala Lumpur, Malaysia 57000
Chew Chian Wei
School of Health Sciences, International Medical University, Kuala Lumpur, Malaysia 57000
Jestin Chellian
Department of Life Sciences, School of Pharmacy, International Medical University (IMU), Bukit Jalil, Kuala Lumpur, 57000, Malaysia
Gaurav Gupta
School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, 302017, Jaipur, India

SINOPSIS

Oral delivery of insulin is one of the most promising and anticipated areas in the treatment of diabetes, primarily because it may significantly improve the quality of life of diabetics who receive insulin regularly. Several problems have been reported regarding the subcutaneous delivery of insulin, ranging from cardiovascular complications to weight gain. One of the approaches to overcoming these issues is to administer insulin through the oral route. However, there are several challenges in developing an oral route for insulin delivery; insulin has extremely poor bioavailability and a low diffusion rate through the mucus layer. A wide range of oral insulin delivery techniques have recently been researched, ranging from nanoparticles to liposomes, self-emulsifying systems, and hydrogels. These techniques have shown promising potential in the oral delivery of insulin. This review considers the current literature on the advances and challenges in the development of oral insulin.


Articles with similar content:

A REVIEW ON RECENT ADVANCEMENTS IN THE HEMODYNAMICS OF NANO-DRUG DELIVERY SYSTEMS
Nanoscience and Technology: An International Journal, Vol.11, 2020, issue 1
B. Vasu, O. Anwar Bég, P. V. S. N. Murthy, Ponnaiah Saikrishnan, Jayati Tripathi, Rama Subba Reddy Gorla, V. Ramachandra Prasad, Ankita Dubey
Advanced Aerosol Delivery Devices for Potential Cure of Acute and Chronic Diseases
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.31, 2014, issue 6
Goutam Rath, Ranjot Kaur, Tarun Garg, Amit Kumar Goyal
A Review of the Application of Lipid-Based Systems in Systemic, Dermal/ Transdermal, and Ocular Drug Delivery
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.25, 2008, issue 6
Kishor M. Wasan, Pavel Gershkovich, Cheri A. Barta
Overview on Therapeutic Applications of Microparticulate Drug Delivery Systems
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.33, 2016, issue 4
Swarna Bale, Mandip Singh, A. Shiva Shankar Reddy, Amit Khurana, Chandraiah Godugu
Conundrum and Therapeutic Potential of Curcumin in Drug Delivery
Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.27, 2010, issue 4
Javed Ali, Sanjula Baboota, Anil Kumar, Alka Ahuja