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Journal of Environmental Pathology, Toxicology and Oncology

Publicado 4 números por año

ISSN Imprimir: 0731-8898

ISSN En Línea: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Distinct Susceptibility to Inoculated Melanoma and Sensitivity to Cancer Pain in Mouse Lines With High and Low Sensitivity to Stress

Volumen 31, Edición 2, 2012, pp. 167-177
DOI: 10.1615/JEnvironPatholToxicolOncol.v31.i2.80
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SINOPSIS

Approximately 30 years ago, we developed 2 mouse lines with enhanced and decreased opioid system activity using bidirectional selection for high (high analgesia [HA] line) and low (low analgesia [LA] line) swim stress-induced analgesia. These mouse lines differ substantially in pain sensitivity, measured as hind paw withdrawal latency in a hot plate test. Moreover, compared with the LA mice, the HA mice exhibited reduced energy expenditure under stress and different depression-like behavior as well as higher sensitivity to mutagens and the high frequency of spontaneous and carcinogen-induced tumors. In the current study, we observed distinct differences in the growth rate of orthotopically implanted melanoma and the onset of cancer pain. Whereas the HA line was prone to tumors and carcinogenesis was rapid in all specimens, the LA mice either did not develop tumors (70%) or developed tumors that often regressed spontaneously (30%). Animals from both lines developed robust thermal hypersensitivity in the tumor-bearing paw compared with animals that were injected with saline. However, we found that hyperalgesia in tumor-bearing mice persists for a much shorter time in the HA than in LA mice. Naltrexone, given subcutaneously, restored hyperalgesia in the HA mice, whereas it was ineffective in the LA mice. The results suggest that activity of the opioid system may influence carcinogenesis and the intensity of cancer pain and indicates that HA and LA mice are good models for such studies.

CITADO POR
  1. Bodnar Richard J., Endogenous opiates and behavior: 2012, Peptides, 50, 2013. Crossref

  2. Ragan Agnieszka R., Lesniak Anna, Bochynska-Czyz Marta, Kosson Anna, Szymanska Hanna, Pysniak Kazimiera, Gajewska Marta, Lipkowski Andrzej W., Sacharczuk Mariusz, Chronic mild stress facilitates melanoma tumor growth in mouse lines selected for high and low stress-induced analgesia, Stress, 16, 5, 2013. Crossref

  3. Lesniak Anna, Chmielewska Diana, Poznanski Piotr, Bujalska-Zadrozny Magdalena, Strzemecka Joanna, Sacharczuk Mariusz, Divergent Response to Cannabinoid Receptor Stimulation in High and Low Stress-Induced Analgesia Mouse Lines Is Associated with Differential G-Protein Activation, Neuroscience, 404, 2019. Crossref

  4. Kokocinska-Kusiak Agata, Matalińska Joanna, Sacharczuk Mariusz, Sobczyńska Magdalena, Góral-Radziszewska Katarzyna, Wileńska Beata, Misicka Aleksandra, Jezierski Tadeusz, Can mice be trained to discriminate urine odor of conspecifics with melanoma before clinical symptoms appear?, Journal of Veterinary Behavior, 39, 2020. Crossref

  5. Lesniak Anna, Poznański Piotr, Religa Piotr, Nawrocka Agata, Bujalska-Zadrozny Magdalena, Sacharczuk Mariusz, Loss of Brain-Derived Neurotrophic Factor (BDNF) Resulting From Congenital- Or Mild Traumatic Brain Injury-Induced Blood–Brain Barrier Disruption Correlates With Depressive-Like Behaviour, Neuroscience, 458, 2021. Crossref

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