Publicado 4 números por año
ISSN Imprimir: 0731-8898
ISSN En Línea: 2162-6537
Indexed in
Distinct Susceptibility to Inoculated Melanoma and Sensitivity to Cancer Pain in Mouse Lines With High and Low Sensitivity to Stress
SINOPSIS
Approximately 30 years ago, we developed 2 mouse lines with enhanced and decreased opioid system activity using bidirectional selection for high (high analgesia [HA] line) and low (low analgesia [LA] line) swim stress-induced analgesia. These mouse lines differ substantially in pain sensitivity, measured as hind paw withdrawal latency in a hot plate test. Moreover, compared with the LA mice, the HA mice exhibited reduced energy expenditure under stress and different depression-like behavior as well as higher sensitivity to mutagens and the high frequency of spontaneous and carcinogen-induced tumors. In the current study, we observed distinct differences in the growth rate of orthotopically implanted melanoma and the onset of cancer pain. Whereas the HA line was prone to tumors and carcinogenesis was rapid in all specimens, the LA mice either did not develop tumors (70%) or developed tumors that often regressed spontaneously (30%). Animals from both lines developed robust thermal hypersensitivity in the tumor-bearing paw compared with animals that were injected with saline. However, we found that hyperalgesia in tumor-bearing mice persists for a much shorter time in the HA than in LA mice. Naltrexone, given subcutaneously, restored hyperalgesia in the HA mice, whereas it was ineffective in the LA mice. The results suggest that activity of the opioid system may influence carcinogenesis and the intensity of cancer pain and indicates that HA and LA mice are good models for such studies.
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Bodnar Richard J., Endogenous opiates and behavior: 2012, Peptides, 50, 2013. Crossref
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Ragan Agnieszka R., Lesniak Anna, Bochynska-Czyz Marta, Kosson Anna, Szymanska Hanna, Pysniak Kazimiera, Gajewska Marta, Lipkowski Andrzej W., Sacharczuk Mariusz, Chronic mild stress facilitates melanoma tumor growth in mouse lines selected for high and low stress-induced analgesia, Stress, 16, 5, 2013. Crossref
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Lesniak Anna, Chmielewska Diana, Poznanski Piotr, Bujalska-Zadrozny Magdalena, Strzemecka Joanna, Sacharczuk Mariusz, Divergent Response to Cannabinoid Receptor Stimulation in High and Low Stress-Induced Analgesia Mouse Lines Is Associated with Differential G-Protein Activation, Neuroscience, 404, 2019. Crossref
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Kokocinska-Kusiak Agata, Matalińska Joanna, Sacharczuk Mariusz, Sobczyńska Magdalena, Góral-Radziszewska Katarzyna, Wileńska Beata, Misicka Aleksandra, Jezierski Tadeusz, Can mice be trained to discriminate urine odor of conspecifics with melanoma before clinical symptoms appear?, Journal of Veterinary Behavior, 39, 2020. Crossref
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Lesniak Anna, Poznański Piotr, Religa Piotr, Nawrocka Agata, Bujalska-Zadrozny Magdalena, Sacharczuk Mariusz, Loss of Brain-Derived Neurotrophic Factor (BDNF) Resulting From Congenital- Or Mild Traumatic Brain Injury-Induced Blood–Brain Barrier Disruption Correlates With Depressive-Like Behaviour, Neuroscience, 458, 2021. Crossref