Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
Journal of Environmental Pathology, Toxicology and Oncology
Factor de Impacto: 1.625 Factor de Impacto de 5 años: 1.63 SJR: 0.402 SNIP: 0.613 CiteScore™: 2.3

ISSN Imprimir: 0731-8898
ISSN En Línea: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.2013008305
pages 329-341

Aqueous Extract of Pecan Nut Shell (Carya illinoensis [Wangenh.] K. Koch) Exerts Protection Against Oxidative Damage Induced by Cyclophosphamide in Rat Testis

Dalila Benvegnu
Universidade Federal da Fronteira Sul
Raquel C. S. Barcelos
Programa de pos-Graduacao em Farmacologia, Universidade Federal de Santa Maria, Rio Grande do Sul, Brazil
Katiane Roversi
Departamento de Fisiologia e Farmacologia, Universidade Federal de Santa Maria, Rio Grande do Sul, Brazil
N. Boufleur
Departamento de Fisiologia e Farmacologia, Universidade Federal de Santa Maria, RS, Brazil
Camila S. Pase
Departamento de Fisiologia e Farmacologia, Universidade Federal de Santa Maria, RS, Brazil
Fabiola Trevizol
Programa de pos-Graduacao em Farmacologia, Universidade Federal de Santa Maria, Rio Grande do Sul, Brazil
Hecson J. Segat
Departamento de Fisiologia e Farmacologia, Universidade Federal de Santa Maria, Rio Grande do Sul, Brazil
Veronica T. Dias
Departamento de Fisiologia e Farmacologia, Universidade Federal de Santa Maria, Rio Grande do Sul, Brazil
Geisa S. Dolci
Programa de pos-Graduacao em Farmacologia, Universidade Federal de Santa Maria, Rio Grande do Sul, Brazil
Caren T. D. Antoniazzi
Programa de pos-Graduacao em Farmacologia, Universidade Federal de Santa Maria, Rio Grande do Sul, Brazil
Patricia Reckziegel
Departamento de Fisiologia e Farmacologia, Universidade Federal de Santa Maria, RS, Brazil
Fernanda Lima
Departamento de Quimica, Universidade Federal de Santa Maria, Rio Grande do Sul, Brazil
Luiz André de Lima
Universidade Federal Rural de Pernambuco
Leandro M. de Carvalho
Departamento de Quimica, Universidade Federal de Santa Maria, Rio Grande do Sul, Brazil
Valdemiro A. da Silva Junior
Departamento de Morfologia e Fisiologia Animal, Universidade Federal Rural de Pernambuco, Pernambuco, Brazil
M.E. Burger
Programa de pós Graduação em Farmacologia, Universidade Federal de Santa Maria, RS, Brazil

SINOPSIS

This study investigated the protective effect of pecan nut (Carya illinoensis) shell aqueous extract (AE) on the oxidative and morphological status of rat testis treated with cyclophosphamide (CP). Wistar rats received water or AE (5%) ad libitum for 37 days. On day 30, half of each group received a single intraperitoneal administration of vehicle or CP 200 mg/kg. After 7 days, the animals were killed and their testis removed. Rats treated with CP presented reduced levels of lactate dehydrogenase, vitamin C, and gluthatione, as well as decreased catalase activity, increased lipid peroxidation levels and superoxide dismutase activity, no alteration in carbonyl protein levels, and a loss of morphological testicular integrity. In contrast, cotreatment with pecan shell AE totally prevented the decrease of lactate dehydrogenase and vitamin C levels and catalase activity and partially prevented the depletion of gluthatione levels. Moreover, it totally prevented the increase in superoxide dismutase activity and lipid peroxidation levels and maintained testicular integrity. These findings show the protective role of pecan shell AE in CP-induced testicular toxicity. The use of this phytotherapy may be considered to minimize deleterious effects related to this chemotherapy.


Articles with similar content:

Protective Effects of a By-Product of the Pecan Nut Industry (Carya illinoensis) on the Toxicity Induced by Cyclophosphamide in Rats Carya illinoensis Protects Against Cyclophosphamide- Induced Toxicity
Journal of Environmental Pathology, Toxicology and Oncology, Vol.29, 2010, issue 3
R.C.S. Barcelos, M.E. Burger, N.M.B. Martins, C. Vareli, Camila S. Pase, L.G. Muller, Patricia Reckziegel, N. Boufleur, Dalila Benvegnu
The Medicinal Cracked-Cap Polypore Mushroom Phellinus rimosus (Higher Basidiomycetes) Attenuates Alloxan-Induced Hyperglycemia and Oxidative Stress in Rats
International Journal of Medicinal Mushrooms, Vol.15, 2013, issue 3
Thekkuttuparambil Ananthanarayanan Ajith, Kainoor K. Janardhanan, Kuttikkadan A. Rony, John Mathew
Hepato- and Nephroprotective Activities of a Nigerian Local King Tuber Oyster Mushroom, Pleurotus tuberregium (Higher Basidiomycetes), in Chemically Induced Organ Toxicities in Rats
International Journal of Medicinal Mushrooms, Vol.16, 2014, issue 4
Stella Amarachi Ihim, Kolawole A. Laiyemo, Chukwuemeka Sylvester Nworu, Peter A. Akah, Loveth E. Ugwu
Jaggery Protects Hepatorenal Injury Induced by Acute Exposure to Carbon Tetrachloride in Wistar rats
Journal of Environmental Pathology, Toxicology and Oncology, Vol.32, 2013, issue 1
Vinay Sharma, Monika Sharma, Chandra Kant Sharma
Antioxidant and Hepatoprotective Effects of Crataegus songarica Methanol Extract
Journal of Environmental Pathology, Toxicology and Oncology, Vol.33, 2014, issue 2
Akbar Masood, Ovais Zargar, Mohammad Afzal Zargar, Showkat Ahmad Ganie, Shajrul Amin, Parvaiz Ahmad Dar, Shayaq Ul Abeer, Rabia Hamid, Tanveer Ali Dar, Bilal Zargar