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Journal of Environmental Pathology, Toxicology and Oncology
Factor de Impacto: 1.625 Factor de Impacto de 5 años: 1.63 SJR: 0.402 SNIP: 0.613 CiteScore™: 2.3

ISSN Imprimir: 0731-8898
ISSN En Línea: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.2013007074
pages 275-288

Fermented Pu-erh Tea Increases In Vitro Anticancer Activities in HT-29 Cells and Has Antiangiogenetic Effects on HUVECs

Xin Zhao
Department of Food Science and Nutrition, Pusan National University, Busan 609-735, South Korea; Department of Biological and Chemical Engineering, Chongqing University of Education, Chongqing 400067, People's Republic of China
Jia-Le Song
Department of Food Science and Nutrition, Pusan National University, Busan, Korea
Jong-Deog Kim
Department of Biotechnology, Research Center on Anti-Obesity and Health Care, Chonnam National University, Yosu, Chonnam, Korea
Jong-Suk Lee
Gyeonggi Biocenter, Gyeonggi Institute of Science and Technology Promotion (GSTEP), Suwon, Gyeonggi-do, Korea
Kun-Young Park
Department of Food Science and Biotechnology, College of Life Sciences, Cha University, Bundang-gu, Seongnam-si, Gyeonggi-do, 13488, Republic of Korea


Pu-erh tea is produced in China and known to possess medicinal properties. The anticancer and antiangiogenesis effects of fermented Pu-erh tea on HT-29 colon cancer cells and human umbilical vein endothelial cells, respectively, were examined. Two kinds of unfermented and fermented Pu-erh tea (Seven-son tea cake Pu-erh tea and Xiaguan bowl tea [X]) and green tea were used. An MTT assay showed fermented Pu-erh tea X (85% inhibition) possessed more potent anticancer activities than unfermented Pu-erh tea X (67% inhibition) and green tea (53% inhibition) (P < 0.05). Moreover, fermented Pu-erh tea X increased the number of apoptotic bodies determined through DAPI staining and flow cytometric analysis. Fermented Pu-erh tea X induced apoptosis indicated by increased expression of Bax, caspase-9, and caspase-3 messenger RNA and decreased expression of Bcl-2. Fermented Pu-erh tea X also had an anti-inflammation effect, shown in decreased expression of nuclear factor-κB-p65, inducible nitric oxide synthase, COX-2 messenger RNA and increased expression of IκB-α. Further, fermented Pu-erh teas showed stronger antiangiogenesis effects than the 2 other types of tea. After fermentation, the concentrations of gallic acid, resorcylic acid, quercetin, and kaempferol in Pu-erh tea were increased. These results collectively indicated that fermented and unfermented Pu-erh teas possess stronger anticancer and antiangiogenesis effects than green tea. Furthermore, fermented Pu-erh tea showed stronger functional activities than unfermented Pu-erh tea.

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