Publicado 4 números por año
ISSN Imprimir: 0731-8898
ISSN En Línea: 2162-6537
Indexed in
Andrographolide inhibits human umbilical vein endothelial cell invasion and migration by regulating MMP-2 and MMP-9 during angiogenesis
SINOPSIS
Angiogenesis, the formation of new blood vessels from pre existing blood vessels, is essential for tumour progression and metastasis. Studies using Human umbilical vein endothelial cells (HUVECs) clearly demonstrated that administration of andrographolide significantly retarded endothelial cell proliferation, migration, invasion and tube formation. Gelatin zymographic analysis showed the inhibitory effect of andrographolide on the activation of matrix metalloproteinases-MMP-2 and MMP-9. The study reveals that andrographolide treatment could inhibit the activation and nuclear translocation of p65, p50, c-Rel subunits of nuclear factor-κB, and other transcription factors such as c-fos, activated transcription factor-2, and cyclic adenosine monophosphate response element-binding protein in B16F-10 melanoma cells. All these results demonstrate that andrographolide inhibits in vitro angiogenesis by inhibiting MMP-2 and MMP-9 and also by regulating the nuclear translocation of transcription factors.
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Ding Qian-hai, Ji Xiao-wei, Cheng Ye, Yu Yuan-quan, Qi Yi-ying, Wang Xiang-hua, Inhibition of matrix metalloproteinases and inducible nitric oxide synthase by andrographolide in human osteoarthritic chondrocytes, Modern Rheumatology, 23, 6, 2013. Crossref
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Zeng Ke-Wu, Li Ning, Dong Xin, Ma Zhi-Zhong, Jiang Yong, Jin Hong-Wei, Tu Peng-Fei, Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis, European Journal of Pharmacology, 714, 1-3, 2013. Crossref
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Chao Che-Yi, Lii Chong-Kuei, Hsu Ya-Ting, Lu Chia-Yang, Liu Kai-Li, Li Chien-Chun, Chen Haw-Wen, Induction of heme oxygenase-1 and inhibition of TPA-induced matrix metalloproteinase-9 expression by andrographolide in MCF-7 human breast cancer cells, Carcinogenesis, 34, 8, 2013. Crossref
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Tan Mei Lan, Lim Lin Ee, The effects ofAndrographis paniculata(Burm.f.) Nees extract and diterpenoids on the CYP450 isoforms’ activities, a review of possible herb–drug interaction risks, Drug and Chemical Toxicology, 38, 3, 2015. Crossref
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Shen Kaikai, Ji Lili, Lu Bin, Xu Chong, Gong Chenyuan, Morahan Grant, Wang Zhengtao, Andrographolide inhibits tumor angiogenesis via blocking VEGFA/VEGFR2-MAPKs signaling cascade, Chemico-Biological Interactions, 218, 2014. Crossref
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Kuttan Girija, Pratheeshkumar Poyil, Manu Kanjoormana Aryan, Kuttan Ramadasan, Inhibition of tumor progression by naturally occurring terpenoids, Pharmaceutical Biology, 49, 10, 2011. Crossref
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Li Guo-feng, Qin Yu-hua, Du Peng-qiang, Andrographolide inhibits the migration, invasion and matrix metalloproteinase expression of rheumatoid arthritis fibroblast-like synoviocytes via inhibition of HIF-1α signaling, Life Sciences, 136, 2015. Crossref
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Lim Jonathan Chee Woei, Chan Tze Khee, Ng David SW, Sagineedu Sreenivasa R, Stanslas Johnson, Wong WS Fred, Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer, Clinical and Experimental Pharmacology and Physiology, 39, 3, 2012. Crossref
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Pratheeshkumar Poyil, Son Young-Ok, Budhraja Amit, Wang Xin, Ding Songze, Wang Lei, Hitron Andrew, Lee Jeong-Chae, Kim Donghern, Divya Sasidharan Padmaja, Chen Gang, Zhang Zhuo, Luo Jia, Shi Xianglin, Afarinkia Kamyar, Luteolin Inhibits Human Prostate Tumor Growth by Suppressing Vascular Endothelial Growth Factor Receptor 2-Mediated Angiogenesis, PLoS ONE, 7, 12, 2012. Crossref
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Shi Dong-liang, Shi Gui-rong, Xie Jing, Du Xu-zhao, Yang Hao, MicroRNA-27a Inhibits Cell Migration and Invasion of Fibroblast-Like Synoviocytes by Targeting Follistatin-Like Protein 1 in Rheumatoid Arthritis, Molecules and Cells, 39, 8, 2016. Crossref
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Ma Yi-Ling, Lin Shih-Wei, Fang Hua-Chang, Chou Kang-Ju, Bee Youn-Shen, Chu Tian-Huei, Chang Ming-Chi, Weng Wen-Tsan, Wu Chang-Yi, Cho Chung-Lung, Tai Ming-Hong, A Novel Poly-Naphthol Compound ST104P Suppresses Angiogenesis by Attenuating Matrix Metalloproteinase-2 Expression in Endothelial Cells, International Journal of Molecular Sciences, 15, 9, 2014. Crossref
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Li Jingjing, Peng Yuran, Li Shang, Sun Yicheng, Chan Judy Yuet-Wa, Cui Guozhen, Wang Decai, Zhou Guo-Chun, Lee Simon Ming-Yuen, Anti-angiogenic activity of a new andrographolide derivative in zebrafish and HUVECs, European Journal of Pharmacology, 789, 2016. Crossref
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Dey Sumit Kumar, Bose Dipayan, Hazra Abhijit, Naskar Subhendu, Nandy Abhishek, Munda Rudra Narayan, Das Subhadip, Chatterjee Nabanita, Mondal Nirup Bikash, Banerjee Sukdeb, Saha Krishna Das, Bauer Joseph Alan, Cytotoxic Activity and Apoptosis-Inducing Potential of Di-spiropyrrolidino and Di-spiropyrrolizidino Oxindole Andrographolide Derivatives, PLoS ONE, 8, 3, 2013. Crossref
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Huang Bin, Peng Yuran, Li Jingjing, Li Shang, Sun Yicheng, Wang Decai, Yang Binrui, Chan Judy Yuet-Wa, Yu Huidong, Leung George Pak-Heng, Hoi Maggie Pui-Man, Zhou Guo-Chun, Lee Simon Ming-Yuen, An andrographolide derivative AGP-26b exhibiting anti-angiogenic activity in HUVECs and zebrafish via blocking the VEGFA/VEGFR2 signaling pathway, Molecular BioSystems, 13, 3, 2017. Crossref
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Ma Jingyi, Zhou Xuelin, Pro-Angiogenic and Anti-Angiogenic Effects of Small Molecules from Natural Products, in Nutraceuticals and Natural Product Derivatives, 2018. Crossref
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Yu Chih-Chia, Chen Chien-An, Fu Shu-Ling, Lin Hon-Yi, Lee Moon-Sing, Chiou Wen-Yen, Su Yu-Chieh, Hung Shih-Kai, Pizzo Salvatore V, Andrographolide enhances the anti-metastatic effect of radiation in Ras-transformed cells via suppression of ERK–mediated MMP-2 activity, PLOS ONE, 13, 10, 2018. Crossref
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Liao Hsin-Chia, Chou Yi-Ju, Lin Ching-Cheng, Liu Sheng-Hung, Oswita Audrey, Huang Yi-Long, Wang Ying-Lien, Syu Jia-Ling, Sun Chung-Ming, Leu Chuen-Miin, Lin Chao-Hsiung, Fu Shu-Ling, Andrographolide and its potent derivative exhibit anticancer effects against imatinib-resistant chronic myeloid leukemia cells by downregulating the Bcr-Abl oncoprotein, Biochemical Pharmacology, 163, 2019. Crossref
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Duan Ming-Xia, Zhou Heng, Wu Qing-Qing, Liu Chen, Xiao Yang, Deng Wei, Tang Qi-Zhu, Andrographolide Protects against HG-Induced Inflammation, Apoptosis, Migration, and Impairment of Angiogenesis via PI3K/AKT-eNOS Signalling in HUVECs, Mediators of Inflammation, 2019, 2019. Crossref
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Yang Shih-Liang, Kuo Fu-Hsuan, Chen Pei-Ni, Hsieh Yi-Hsien, Yu Nuo-Yi, Yang Wei-En, Hsieh Ming-Ju, Yang Shun-Fa, Andrographolide suppresses the migratory ability of human glioblastoma multiforme cells by targeting ERK1/2-mediated matrix metalloproteinase-2 expression, Oncotarget, 8, 62, 2017. Crossref
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Cui Kaixuan, Liu Jian, Huang Lili, Qin Bai, Yang Xiaowei, Li Lele, Liu Yu, Gu Jiayi, Wu Wenli, Yu Ying, Sang Aimin, Andrographolide attenuates choroidal neovascularization by inhibiting the HIF-1α/VEGF signaling pathway, Biochemical and Biophysical Research Communications, 530, 1, 2020. Crossref
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Paul Silpita, Roy Dia, Pati Subhadip, Sa Gaurisankar, The Adroitness of Andrographolide as a Natural Weapon Against Colorectal Cancer, Frontiers in Pharmacology, 12, 2021. Crossref
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Gupta Swati, Mishra KP, Gupta Rupali, Singh SB, Andrographolide – A prospective remedy for chikungunya fever and viral arthritis, International Immunopharmacology, 99, 2021. Crossref
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Islam Muhammad Torequl, Ali Eunüs S., Uddin Shaikh Jamal, Islam Md. Amirul, Shaw Subrata, Khan Ishaq N., Saravi Seyed Soheil Saeedi, Ahmad Saheem, Rehman Shahnawaz, Gupta Vijai Kumar, Găman Mihnea-Alexandru, Găman Amelia Maria, Yele Santosh, Das Asish Kumar, de Castro e Sousa João Marcelo, de Moura Dantas Sandra Maria Mendes, Rolim Hercília Maria Lins, de Carvalho Melo-Cavalcante Ana Amélia, Mubarak Mohammad S., Yarla Nagendra Sastry, Shilpi Jamil A., Mishra Siddhartha Kumar, Atanasov Atanas G., Kamal Mohammad Amjad, Andrographolide, a diterpene lactone from Andrographis paniculata and its therapeutic promises in cancer, Cancer Letters, 420, 2018. Crossref
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Gupta Swati, Mishra K. P., Ganju Lilly, Broad-spectrum antiviral properties of andrographolide, Archives of Virology, 162, 3, 2017. Crossref
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Kanellopoulou Vasiliki Κ., Xanthopoulos Athanasios, Mikelis Constantinos Marios, Papadimitriou Evangelia, Collagens and Collagen-Degrading Enzymes in the Regulation of Angiogenesis, in Matrix Pathobiology and Angiogenesis, 12, 2023. Crossref