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Journal of Environmental Pathology, Toxicology and Oncology

Publicado 4 números por año

ISSN Imprimir: 0731-8898

ISSN En Línea: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Evaluation of Anti-Nociceptive and Anti-Inflammatory Effect of Luteolin in Mice

Volumen 37, Edición 4, 2018, pp. 351-364
DOI: 10.1615/JEnvironPatholToxicolOncol.2018027666
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SINOPSIS

Flavonoids are polyphenolic compounds that not only impart coloration to plants and fruits, but also protect plants from pathogens, radiation, etc. They serve as a nutrient to plants and possess immense anti-oxidant properties. Research has shown that they exhibit anti-inflammatory, anti-cancer, and neuroprotective properties in both in vitro and in vivo analyses. Luteolin is one such flavonoid belongs to the group of flavones present in herbs such as thyme, chamomile, celery, and green pepper. The epidemiological data on luteolin consumption show that luteolin has anti-inflammatory activity and protects from diseases associated with inflammation. The present study assessed the anti-nociceptive properties of luteolin, a potent anti-inflammatory agent, in mice. The results demonstrated that luteolin produces a significant and dose-dependent increase in hot plate latency and tail withdrawal time. It also reduced the number of abdominal constrictions and paw licking induced by acetic acid and glutamate, respectively. Luteolin inhibited the nociceptive responses in both phases of formalin test. The anti-inflammatory property of luteolin was also confirmed with different anti-inflammatory mice models induced by carrageenan and air pouch. Behavioral changes in luteolin-treated mice were assessed with open-field test to confirm the muscle relaxant property. The results of the current study from various pain and inflammatory models confirms that luteolin possess potent anti-nociceptive and anti-inflammatory properties and can thus be used as a drug in pain management.

CITADO POR
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  2. Casili Giovanna, Ardizzone Alessio, Lanza Marika, Gugliandolo Enrico, Portelli Marco, Militi Angela, Cuzzocrea Salvatore, Esposito Emanuela, Paterniti Irene, Treatment with Luteolin Improves Lipopolysaccharide-Induced Periodontal Diseases in Rats, Biomedicines, 8, 10, 2020. Crossref

  3. Miere (Groza) Florina, Teușdea Alin Cristian, Laslo Vasile, Cavalu Simona, Fritea Luminița, Dobjanschi Luciana, Zdrinca Mihaela, Zdrinca Marcel, Ganea Mariana, Pașc Priscilla, Memete Adriana Ramona, Antonescu Angela, Vlad Andreea Margareta, Vicas Simona Ioana, Evaluation of In Vitro Wound-Healing Potential, Antioxidant Capacity, and Antimicrobial Activity of Stellaria media (L.) Vill, Applied Sciences, 11, 23, 2021. Crossref

  4. Shanaida Mariia, Hudz Nataliia, Jasicka-Misiak Izabela, Wieczorek Piotr P., Polyphenols and Pharmacological Screening of a Monarda fistulosa L. dry Extract Based on a Hydrodistilled Residue By-Product, Frontiers in Pharmacology, 12, 2021. Crossref

  5. Peng Yu, Tao Hongxun, Yang Yuanyuan, Gao Yuanqing, Ren Hui, Hu Jing, Chen Zhiyong, Li Ye, Chemical compositions, pharmacological activities, quality control studies of Erycibes plants, and the development of their substitutes , Phytotherapy Research, 35, 8, 2021. Crossref

  6. Zeng Yijia, Lou Guanhua, Ren Yuanyuan, Li Tingna, Zhang Xiaorui, Wang Jin, Huang Qinwan, Network pharmacology-based analysis of Zukamu granules for the treatment of COVID-19, European Journal of Integrative Medicine, 42, 2021. Crossref

  7. do Carmo Paula Lima, Mello Renata de Jesus, Ramos Igor Frederico de Oliveira, de Jesus Cristiane Catela Martins, Pontes Raissa Gabriela Menezes dos Santos, de Araújo Marlon Heggdorne, Bonavita André Gustavo Calvano, Pinto Shaft Corrêa, Muzitano Michelle Frazão, Raimundo Juliana Montani, Analgesic and anti-inflammatory activities of ethyl acetate and butanol fractions from Vitex polygama hydroalcoholic leaf extract, Natural Product Research, 2022. Crossref

  8. Wu Zhaojing, Yang Qing, Ma Hongbo, Siddiqui Arif Jamal, Study the Mechanism of Gualou Niubang Decoction in Treating Plasma Cell Mastitis Based on Network Pharmacology and Molecular Docking, BioMed Research International, 2022, 2022. Crossref

  9. Ansari Mohammad Javed, Alshetaili Abdullah, Aldayel Ibrahim Abdulaziz, Alablan Faisal Mohammed, Alsulays Bader, Alshahrani Saad, Alalaiwe Ahmad, Ansari Mohd Nazam, Ur Rehman Najeeb, Shakeel Faiyaz, Formulation, characterization, in vitro and in vivo evaluations of self-nanoemulsifying drug delivery system of luteolin, Journal of Taibah University for Science, 14, 1, 2020. Crossref

  10. Qi Yajun, Fu Shuang, Pei Donggen, Fang Qilu, Xin Wenxiu, Yuan Xiaohong, Cao Yingying, Shu Qi, Mi Xiufang, Luo Fang, Luteolin attenuated cisplatin-induced cardiac dysfunction and oxidative stress via modulation of Keap1/Nrf2 signaling pathway, Free Radical Research, 56, 2, 2022. Crossref

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  12. Zheng Hao, Zhu Xiaoyu, Gong Enhui, Lv Yuankai, Li Yuling, Cai Xiaoping, Luteolin suppresses lung cancer progression through targeting the circ_0000190/miR-130a-3p/notch-1 signaling pathway, Journal of Chemotherapy, 2022. Crossref

  13. Chagas Maria do Socorro S., Behrens Maria D., Moragas-Tellis Carla J., Penedo Gabriela X. M., Silva Adriana R., Gonçalves-de-Albuquerque Cassiano F., Angeloni Cristina, Flavonols and Flavones as Potential anti-Inflammatory, Antioxidant, and Antibacterial Compounds, Oxidative Medicine and Cellular Longevity, 2022, 2022. Crossref

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