Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
Journal of Environmental Pathology, Toxicology and Oncology
Factor de Impacto: 1.241 Factor de Impacto de 5 años: 1.349 SJR: 0.356 SNIP: 0.613 CiteScore™: 1.61

ISSN Imprimir: 0731-8898
ISSN En Línea: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.v21.i2.60
9 pages

Effects of Yakuchinone A and Yakuchinone В on the Phorbol Ester-Induced Expression of COX-2 and iNOS and Activation of NF-kB in Mouse Skin

Kyung-Soo Chun
Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, South Korea
Jee-Young Kang
Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, South Korea
Ok Hee Kim
Korea Food and Drug Administration, Seoul, South Korea
Hoil Kang
Korea Food and Drug Administration, Seoul, South Korea
Young-Joon Surh
Seoul National University, South Korea

SINOPSIS

Certain medicinal plants contain anti-inflammatory and antioxidative substances that can exert chemopreventive effects. Our previous studies have demonstrated that the methanol extract of Alpinia oxyphylla Miquel (Zingiberaceae) inhibits tumor promotion in mouse skin. Two major diarylheptanoids named yakuchinone A (l-[4'-hydroxy-3'-methoxyphenyl]-7-phenyl-3-heptanone) and yakuchinone В (l-[4'-hydroxy-3'-methoxyphenyl]-7-phenylhept-l-en-3-one) have been isolated from this medicinal plant. Both compounds have strong inhibitory effects on the synthesis of prostaglandins and leukotrienes in vitro. In the present work, we show that both yakuchinone A and yakuchinone В inhibit the expression of cyclooxygenase-2 (COX-2) and of inducible nitric oxide synthase (iNOS) as well as the expression of tumor necrosis factor (TNF)-a mRNA in mouse skin treated with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Topical application on mouse skin of these diarylheptanoids also attenuated the TPA-induced DNA binding activity of the ubiquitous eukaryotic transcription factor NF-kB that plays a crucial role in regulating the expression of the aforementioned proinflammatory enzymes and cytokines in response to a wide variety of external stimuli. These findings suggest that diarylheptanoids contained in Alpinia oxyphylla down-regulate COX-2 and iNOS expression through suppression of NF-kB activation in the TPA-treated mouse skin.


Articles with similar content:

Oxidant-Sensitive Transcription Factor and Cyclooxygenase-2 by Helicobacter pylori Stimulation in Human Gastric Cancer Cells
Journal of Environmental Pathology, Toxicology and Oncology, Vol.21, 2002, issue 2
Jeong Yeon Seo, Joo Weon Lim, Kyung Hwan Kim, Hyeyoung Kim
Medicinal Mushroom Lingzhi or Reishi, Ganoderma lucidum (W.Curt.:Fr.) P. Karst., β-Glucan Induces Toll-like Receptors and Fails to Induce Inflammatory Cytokines in NF-κB Inhibitor-Treated Macrophages
International Journal of Medicinal Mushrooms, Vol.13, 2011, issue 3
Mi Jeong Kim, Ha Won Kim, Sainkhuu Batbayar
In vitro Synthesis of a Recombinant Fungal Immunomodulatory Protein from Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (W.Curt.:Fr.) P.Karst. (Aphyllophoromycetideae) and Analysis of Its Immunomodulatory Activity
International Journal of Medicinal Mushrooms, Vol.12, 2010, issue 4
Xuan-Wei Zhou, Ting-wen Bao, Xue-fei Wang, Qi-zhang Li, Juan Lin, Liang Ran
Anti-Inflammatory Activity and Bioactive Constituents of Cultivated Fruiting Bodies of Xylaria nigripes (Ascomycetes), a Chinese Medicinal Fungus
International Journal of Medicinal Mushrooms, Vol.19, 2017, issue 10
Shu-Jing Wu, Ching-Fu Chen, Chih-Chuang Liaw, Lean-Teik Ng, Ming-Nan Lai
Anti-Inflammatory and Apoptotic Signaling Effect of Fucoxanthin on Benzo(A)Pyrene-Induced Lung Cancer in Mice
Journal of Environmental Pathology, Toxicology and Oncology, Vol.38, 2019, issue 3
Hongjing Zhang, Yue Liu, Weiwei Chen