Suscripción a Biblioteca: Guest
Journal of Environmental Pathology, Toxicology and Oncology

Publicado 4 números por año

ISSN Imprimir: 0731-8898

ISSN En Línea: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Partially Purified Aqueous Fraction of Desmodium gyrans DC Improves Reverse Cholesterol Transport and Lipoprotein Metabolism in Wistar Rats Fed with High Fat Diet

Volumen 37, Edición 1, 2018, pp. 27-41
DOI: 10.1615/JEnvironPatholToxicolOncol.2018025265
Get accessGet access

SINOPSIS

Apart from the conventional hypolipidemic therapy, plaque regression through enhanced reverse cholesterol transport (RCT) has emerged as novel approach in atherosclerotic drug development. High-density lipoprotein (HDL) mimetics as well as agents that augment the functional HDL and RCT pathways are under intense exploration. Desmodium gyrans (Fabacea) has been shown to have hypolipidemic efficacy, with an HDL-enhancing property. In this study, a chromatographically purified active fraction of D. gyrans (DGMAF) significantly decreased the serum and lipid profiles as well as lipotoxicity in liver in Wistar rats fed with high-fat diet (HFD). Except for the marginal deposition of liver lipids, all other organs showed no weight gain due to lipid accumulation. A lower level of lipid peroxidation and a reduced atherogenic index suggests the hypolipidemic efficacy of DGMAF, which was comparatively higher than clinically used atorvastatin. Furthermore, the DGMAF-treated animals had enhanced levels of HDL, associated ApoA-1, and paraoxonase activity. The mRNA levels of ApoA-1 and SR-B1 were upregulated, and cholesteryl ester transfer protein (CETP) was downregulated. Overall, the results of this study indicate that D. gyrans augments the RCT pathway and improves the lipid metabolism in rats fed an HFD.

PALABRAS CLAVE: DGMAF, HDL, RCT, SR-BI, ApoA-1, CETP
1204 Vistas de artículos 20 Descargas de artículos Métrica
1204 PUNTOS DE VISTA 20 DESCARGAS Google
Scholar
CITAS

Artículos con contenido similar:

Antiatherosclerotic Activity of Eriocitrin in High-Fat-Diet-Induced Atherosclerosis Model Rats Journal of Environmental Pathology, Toxicology and Oncology, Vol.39, 2020, issue 1
Lingjuan Du, Shikui Guo, Yaoyu Feng, Vishnu Priya Veeraraghavan, Surapaneni Krishna Mohan, Jia Wan
The Action of Higher Basidiomycetes Mushrooms Mycelia on Plasma Lipids and Lipoproteins of Hyperlipidemic Rats and Guinea Pigs International Journal of Medicinal Mushrooms, Vol.1, 1999, issue 4
Olga V. Remesova , Nina P. Denisova
Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes): A Species with Antioxidant, Immunomodulatory, and Hepatoprotective Activities in Hypercholesterolemic Rats International Journal of Medicinal Mushrooms, Vol.19, 2017, issue 11
Haseeb Anwar, Jaweria Nisar, Ghulam Hussain, Shazia Anwer Bukhari, Muhammad Naeem Faisal, Muhammad Irfan Ullah, Abdul Basit, Imtiaz Mustafa, Muhammad Umar Sohail
Hypolipidemic and Antiatherogenesis Effect of Culinary-Medicinal Pink Oyster Mushroom, Pleurotus salmoneostramineus L. Vass. (Higher Basidiomycetes), in Hypercholesterolemic Rats International Journal of Medicinal Mushrooms, Vol.14, 2012, issue 1
Ki Nam Yoon, Nuhu Alam, Tae Soo Lee, Mi Ja Shim
Antihyperglycemic and Antilipidperoxidative Effects of Polysaccharides Extracted from Medicinal Mushroom Chaga, Inonotus obliquus (Pers.: Fr.) Pilát (Aphyllophoromycetideae) on Alloxan-Diabetes Mice International Journal of Medicinal Mushrooms, Vol.12, 2010, issue 3
Yitong Zheng, Hong-Yu Xu, Xin Xu, Zhenming Lu, Chengjian Yang, Zheng-Hong Xu, Chong Pang
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones Precios y Políticas de Suscripcione Begell House Contáctenos Language English 中文 Русский Português German French Spain