Publicado 4 números por año
ISSN Imprimir: 0731-8898
ISSN En Línea: 2162-6537
Indexed in
Oxidative Stress−Mediated Apoptotic Death in Human Peripheral Blood Lymphocytes Treated with Plasma from Gamma-Irradiated Blood
SINOPSIS
The present study is aimed to investigate the effect of plasma from irradiated human blood on the induction of apoptotic death in human peripheral blood lymphocytes. Our results showed that plasma obtained from γ-irradiated human blood showed a significant decrease in viability and an increase in apoptotic death in unirradiated lymphocytes, which is correlated with increase in intracellular reactive oxygen species level. Moreover, a decrease in the activity of superoxide dismutase in lymphocytes further seems to be associated with oxidative stress−mediated apoptotic death. The diffusible factors from irradiated blood were found to be generated from the cellular components of blood. Based on our results, we suggest induction of oxidative stress−mediated apoptotic death in unirradiated lymphocytes by diffusible factors from irradiated blood.
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Renčko Andrej, Ondrašovičová Silvia, Sopková Drahomíra, Ondrašovičová Jana, Effect of gamma-irradiation on the differential leukocyte count in fish Poecilia reticulata, Acta Veterinaria Brno, 83, 3, 2014. Crossref