Suscripción a Biblioteca: Guest
Journal of Environmental Pathology, Toxicology and Oncology

Publicado 4 números por año

ISSN Imprimir: 0731-8898

ISSN En Línea: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Evaluation of Radioprotective Action of Compounds Using Saccharomyces cerevisiae

Volumen 23, Edición 2, 2004, 8 pages
DOI: 10.1615/JEnvPathToxOncol.v23.i2.70
Get accessGet access

SINOPSIS

The yeast Saccharomyces cerevisiae serves as a model eukaryotic system to screen radioprotectors that can be used primarily in radiotherapy as well as in occupational workers in nuclear and allied industries. A number of antioxidants are suggested to be radioprotectors by virtue of their ability to quench reactive oxygen species, but their radioprotective action has not been investigated so far. In this study, a number of antioxidants were tested for their efficacy in radioprotection using yeast cells. Sulfhydryl compounds (disulfiram at 100 and 200 μM) and reduced glutathione (10 and 100 mM), purified compounds of plant origin, such as curcumin (1 mM, 10 mM, and 100 mM), quercetin (100 and 500 μM), rutin (100 and 200 μM), ellagic acid (100,200, and 500 μM) and gallic acid (100 and 500 μM)—were studied. The results revealed that all compounds, except gallic acid, specifically protected normal yeast cells from γ-radiation damage. Using rad 52 mutants, which lack recombinational DNA repair pathway, it has been found that protection was solely brought about by reducing DNA damage rather than by interfering with DNA repair. Results with DNA repair polymerase further substantiated this contention. We conclude that simple eukaryotic yeast cells can serve as a test system not only for rapid screening of radiomodifiers but also to study their mode of action.

CITADO POR
  1. NEMAVARKAR P. S., CHOURASIA B. K., PASUPATHY K., Detection of γ-Irradiation Induced DNA Damage and Radioprotection of Compounds in Yeast Using Comet Assay, Journal of Radiation Research, 45, 2, 2004. Crossref

  2. TAMURA Sayaka, WADA Chiaki, HASE Akira, KANAMITSU Kyoichiro, IKEDA Shogo, A Simple Growth Test of a Saccharomyces cerevisiae Cu, Zn-Superoxide Dismutase-Deficient Mutant in Hypertonic Medium for Biological Evaluation of Antioxidants, Food Science and Technology Research, 16, 3, 2010. Crossref

  3. Mandal Shramana, Mandal Ashish Kumar, Malignant fibrous histiocytoma following radiation therapy and chemotherapy for Hodgkin's lymphoma, International Journal of Clinical Oncology, 12, 1, 2007. Crossref

  4. Kma Lakhan, Plant Extracts and Plant-Derived Compounds: Promising Players in Countermeasure Strategy Against Radiological Exposure: A Review, Asian Pacific Journal of Cancer Prevention, 15, 6, 2014. Crossref

  5. Swami Shrikant Baslingappa, Thakor Nayan Singh J., Patil Meghatai M., Haldankar Parag M., Jamun (<i>Syzygium cumini </i>(L.)): A Review of Its Food and Medicinal Uses, Food and Nutrition Sciences, 03, 08, 2012. Crossref

  6. Pareek Sunil, Shikov Alexander N., Pozharitskaya Olga N., Makarov Valery G., González-Aguilar Gustavo A., Ramalho Suyare A., Narain Narendra, Indian Gooseberry (Emblica officinalisGaertn.), in Fruit and Vegetable Phytochemicals, 2017. Crossref

  7. Muthukumaran Selva, Tranchant Carole, Shi John, Ye Xingqian, Xue Sophia Jun, Ellagic acid in strawberry (Fragaria spp.): Biological, technological, stability, and human health aspects, Food Quality and Safety, 1, 4, 2017. Crossref

  8. Kim Wanyeon, Kang Jihoon, Lee Sungmin, Youn Buhyun, Effects of traditional oriental medicines as anti-cytotoxic agents in radiotherapy, Oncology Letters, 13, 6, 2017. Crossref

  9. Jagetia Ganesh C., RADIOPROTECTION AND RADIOSENSITIZATION BY CURCUMIN, in The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease, 595, 2007. Crossref

  10. Mielczarek Jakub, Zadrożny Adam, A Concept of Biopharmaceutical Nanosatellite, New Space, 7, 2, 2019. Crossref

  11. Tesson Mathias, Anselmi Giorgio, Bell Caitlin, Mairs Robert, Cell cycle specific radiosensitisation by the disulfiram and copper complex, Oncotarget, 8, 39, 2017. Crossref

  12. Kudva Avinash Kundadka, Raghu Shamprasad Varija, Rao Suresh, Venkatesh Ponemone, Hegde Sanath Kumar, D’souza Rhea Katherine, Baliga-Rao Manjeshwar Poonam, Simon Paul, Baliga Manjeshwar Shrinath, Indian Indigenous Fruits as Radioprotective Agents: Past, Present and Future, Anti-Cancer Agents in Medicinal Chemistry, 22, 1, 2022. Crossref

  13. Kudva Avinash Kundadka, Baliga Manjeshwar Shrinath, Raghu Shamprasad Varija, Pharmacological Application of Phyllanthus emblica as Therapeutics in Alzheimer’s Disease, in Functional Foods and Therapeutic Strategies for Neurodegenerative Disorders, 2022. Crossref

  14. Kawvised Supannika, Prabsattroo Thawatchai, Munkong Waranon, Pattum Panuwat, Iamsaard Sittichai, Boonsirichai Kanokporn, Uttayarat Pimporn, Maikaeo Lamai, Sudchai Waraporn, Kirisattayakul Woranan, Polygonum odoratum leaf extract attenuates oxidative stress and cell death of Raw 264.7 cells exposed to low dose ionizing radiation , Journal of Food Biochemistry, 46, 4, 2022. Crossref

Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones Precios y Políticas de Suscripcione Begell House Contáctenos Language English 中文 Русский Português German French Spain