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Journal of Environmental Pathology, Toxicology and Oncology

Publicado 4 números por año

ISSN Imprimir: 0731-8898

ISSN En Línea: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Alterations in Colonic Barrier Function Caused By a Low Sodium Diet or Ionizing Radiation

Volumen 23, Edición 2, 2004, 20 pages
DOI: 10.1615/JEnvPathToxOncol.v23.i2.10
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SINOPSIS

This article reviews how cytokines and radiation-induced apoptosis affect the barrier function of the colonic pericryptal sheath and thereby colonic crypt fluid absorption. A layer of myofibroblasts forming a pericryptal sheath surrounds the colonic crypt epithelial cells. The colonic pericryptal hypertonicity (250—350 mM NaCl) resulting from Na+ pumping into the space between the crypt epithelial cells and the myofibroblasts provides the driving force required to produce the suction tension (5—10 atmospheres) that dehydrates feces. [Na+] in the pericryptal space and crypt lumen is monitored in vivo with a Na+ ion-sensitive fluorescent dye, Sodium Red. Dietary Na+ restriction increases this hypertonicity. The rate of dextran—labeled with fluorescein isothiocyanate (FITC)—accumulation in the crypt lumen monitors fluid absorption by the crypt lumen. The rate of leakage of FITC dextran (10 kDa) across the crypt wall reflects its permeability. With low Na+ intake, there is decreased crypt luminal dextran permeability. This decrease in crypt permeability is due to increased systemic and local release of angiotensin II and TGF-β and is accompanied by pericryptal growth stimulation with consequent increased expression of myofibroblast proteins, smooth muscle actin, collagen 4, and OB cadherin. Inhibition of cytokine formation by the angiotensin-converting enzyme inhibitor (ACEI) captopril prevents these trophic effects. Colonic fluid absorption is inhibited 4 days after whole-body exposure to ionizing radiation of >8 Gy. Concurrently, there is loss of the pericryptal myofibroblasts resulting from apoptosis, with consequent loss of the barrier function of the pericryptal sheath. These effects cause increased rates of dextran leakage across the crypt wall and loss of myofibroblast markers. Normal colonic function returns after 10 days accompanied by repair of the pericryptal sheath. The caspase inhibitor, Z-VAD Fmk, reduces sheath apoptosis. Longer term irradiation of >8 Gy produces overgrowth of the myofibroblasts and fibrosis, which is inhibited by captopril.

CITADO POR
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