Suscripción a Biblioteca: Guest
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones
Journal of Environmental Pathology, Toxicology and Oncology
Factor de Impacto: 1.241 Factor de Impacto de 5 años: 1.349 SJR: 0.519 SNIP: 0.613 CiteScore™: 1.61

ISSN Imprimir: 0731-8898
ISSN En Línea: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.v30.i2.70
pages 163-178

Ipobscurine, an Indole Alkaloid from Ipomoea obscura, Inhibits Tumor Cell Invasion and Experimental Metastasis by Inducing Apoptosis

T. P. Hamsa
Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala, India
Girija Kuttan
Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala State, India

SINOPSIS

In the present study, we demonstrate that ipobscurine, an indole alkaloid fraction isolated from Ipomoea obscura, can reduce the formation of B16F-10 melanoma–induced metastatic nodules and inhibit the proliferation, migration, and invasion of B16F-10 melanoma cells in vitro, possibly by inhibiting pro-metastatic genes such as matrix metalloproteinases (MMPs) and inflammatory mediators such as cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and pro-inflammatory cytokines. Ipobscurine may also promote apoptosis by up-regulating pro-apoptotic molecules such as caspase-3, p53, and Bax and by down-regulating anti-apoptotic Bcl-2. In addition, we have observed that ipobscurine suppresses various transcription factors such as nuclear factor-κB (NF-κB) and activator protein, which are possibly associated with the suppression of apoptosis in cancer cells. Ipobscurine has also been shown to inhibit cell growth with arrest at G1 and reduce transition to the S and G2/M phases of the cell cycle.


Articles with similar content:

Diallyl Disulfide Induces Caspase-Dependent Apoptosis via Mitochondria-Mediated Intrinsic Pathway in B16F-10 Melanoma Cells by Up-Regulating P53, Caspase-3 and Down-Regulating Pro-Inflammatory Cytokines and Nuclear Factor- κβ-Mediated Bcl-2 Activation
Journal of Environmental Pathology, Toxicology and Oncology, Vol.29, 2010, issue 2
P. Pratheeshkumar, Girija Kuttan, P. Thejass
Protective Effect of Solanum muricatum on Tumor Metastasis by Regulating Inflammatory Mediators and Nuclear Factor-Kappa B Subunits
Journal of Environmental Pathology, Toxicology and Oncology, Vol.34, 2015, issue 3
Chandrasekaran Guruvayoorappan, Kittappa Shathish, Kunnathur Murugesan Sakthivel
Chemoprevention of Colon Cancer by iNOS-Selective Inhibitors
Forum on Immunopathological Diseases and Therapeutics, Vol.3, 2012, issue 2
Chinthalapally V. Rao, Naveena B. Janakiram
Vanadate Induces G2/M Phase Arrest in p53-Deficient Mouse Embryo Fibroblasts
Journal of Environmental Pathology, Toxicology and Oncology, Vol.21, 2002, issue 3
Fei Chen, Zhuo Zhang, Chuanshu Huang, Xianglin Shi
Effect of Amentoflavone, a Phenolic Component From Biophytum sensitivum, on Cell Cycling and Apoptosis of B16F-10 Melanoma Cells
Journal of Environmental Pathology, Toxicology and Oncology, Vol.30, 2011, issue 4
K.S. Siveen , Girija Kuttan