Suscripción a Biblioteca: Guest
Journal of Environmental Pathology, Toxicology and Oncology

Publicado 4 números por año

ISSN Imprimir: 0731-8898

ISSN En Línea: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Acceder(open in a new tab)
Más
Comprar $35.00(open in a new tab) Comprobar suscripción Descargar registro MARC(open in a new tab) Obtener permisos(open in a new tab)

Eupatilin, a Pharmacologically Active Flavone Derived from Artemisia Plants, Induces Apoptosis in Human Gastric Cancer (AGS) Cells

Volumen 24, Edición 4, 2005, pp. 261-270
DOI: 10.1615/JEnvironPatholToxicolOncol.v24.i4.30
Get accessGet access
Min-Jung Kim
National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Seoul, South Korea
Do-Hee Kim
National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Seoul, South Korea
Hye-Kyung Na
National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Seoul, South Korea
Tae Young Oh
Dong-A Pharmaceutical Co. Ltd., Kyunggido, South Korea
Chang-Yell Shin
Dong-A Pharmaceutical Co. Ltd., Kyunggido, South Korea
Young-Joon Surh
Seoul National University, South Korea

SINOPSIS

Extracts of Artemisia asiatica Nakai (Asteraceae) possess anti-inflammatory and antioxidative activities. Eupatilin (5,7-dihydroxy-3′,4′, 6-trimethoxyflavone), one of the pharmacologically active ingredients derived from A. asiatica was shown to induce apoptosis in human promyelocytic leukemia (HL-60) cells. In the present study, we examined the ability of eupatilin to induce apoptosis in human gastric cancer (AGS) cells. Eupatilin induced the apoptosis of AGS cells as revealed by a decrease in the ratio of pro-apoptotic Bax and anti-apoptotic Bcl-2, as well as the cleavage of caspase-3 and poly(ADP-ribose)polymerase (PARP).The pro-apoptotic effects of eupatilin were further verified by its perturbation of the mitochondrial transmembrane potential (ΔΨm). In addition, eupatilin treatment led to an elevated expression of p53 and p21. Eupatilin inhibited the activation of ERK1/2 and Akt, which are important components of cell-survival pathways.

CITADO POR

  1. Gómez-Serranillos Cuadrado María, Ortega Hernández-Agero María, Palomino Ruiz-Poveda Olga, Carretero Accame María, Advances in Medicinal Plants with Antitumoral Activity, in Medicinal Plants, 2012. Crossref

  2. Ahn Joong-Bae, Hur Ji-Na, Jung Hae-Gon, Park Jong-Ho, Study on the Growth Environment of 'Gangwha-mugwort' Through the Climatological Characteristic Analysis of Gangwha Region, Korean Journal of Agricultural and Forest Meteorology, 14, 2, 2012. Crossref

  3. Park Byeong Bae, Yoon Jin sun, Kim Eun shil, Choi Jiyoung, Won Young woong, Choi Jung hye, Lee Young Yiul, Inhibitory effects of eupatilin on tumor invasion of human gastric cancer MKN-1 cells, Tumor Biology, 34, 2, 2013. Crossref

  4. Ju Hye-Kyung, Lee Heon-Woo, Chung Kyung-Sook, Choi Jung-Hye, Cho Jin-Gyeong, Baek Nam-In, Chung Hae-Gon, Lee Kyung-Tae, Standardized flavonoid-rich fraction of Artemisia princeps Pampanini cv. Sajabal induces apoptosis via mitochondrial pathway in human cervical cancer HeLa cells, Journal of Ethnopharmacology, 141, 1, 2012. Crossref

  5. Vermeulen E., Zamora-Ros R., Duell E. J., Lujan-Barroso L., Boeing H., Aleksandrova K., Bueno-de-Mesquita H. B., Scalbert A., Romieu I., Fedirko V., Touillaud M., Fagherazzi G., Perquier F., Molina-Montes E., Chirlaque M.-D., Vicente Arguelles M., Amiano P., Barricarte A., Pala V., Mattiello A., Saieva C., Tumino R., Ricceri F., Trichopoulou A., Vasilopoulou E., Ziara G., Crowe F. L., Khaw K.-T., Wareham N. J., Lukanova A., Grote V. A., Tjonneland A., Halkjaer J., Bredsdorff L., Overvad K., Siersema P. D., Peeters P. H. M., May A. M., Weiderpass E., Skeie G., Hjartaker A., Landberg R., Johansson I., Sonestedt E., Ericson U., Riboli E., Gonzalez C. A., Dietary Flavonoid Intake and Esophageal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition Cohort, American Journal of Epidemiology, 178, 4, 2013. Crossref

  6. Yoon Kee Dong, Chin Young-Won, Yang Min Hye, Kim Jinwoong, Separation of anti-ulcer flavonoids from Artemisia extracts by high-speed countercurrent chromatography, Food Chemistry, 129, 2, 2011. Crossref

  7. Choi Seul Min, Shin Jee Hyun, Kang Kyung Koo, Ahn Byoung Ok, Yoo Moohi, Gastroprotective Effects of DA-6034, a New Flavonoid Derivative, in Various Gastric Mucosal Damage Models, Digestive Diseases and Sciences, 52, 11, 2007. Crossref

  8. Kim Bo-Min, Kim Do-Hee, Park Jeong-Hill, Na Hye-Kyung, Surh Young-Joon, Ginsenoside Rg3Induces Apoptosis of Human Breast Cancer (MDA-MB-231) Cells, Journal of Cancer Prevention, 18, 2, 2013. Crossref

  9. Kim Young-Dae, Choi Suck-Chei, Oh Tae-Young, Chun Jang-Soo, Jun Chang-Duk, Eupatilin inhibits T-cell activation by modulation of intracellular calcium flux and NF-κB and NF-AT activity, Journal of Cellular Biochemistry, 108, 1, 2009. Crossref

  10. Ryoo Seung-Bum, Oh Heung-Kwon, Yu Sung A, Moon Sang Hui, Choe Eun Kyung, Oh Tae Young, Park Kyu Joo, The Effects of Eupatilin (Stillen®) on Motility of Human Lower Gastrointestinal Tracts, The Korean Journal of Physiology & Pharmacology, 18, 5, 2014. Crossref

  11. Cho Jung-Hoon, Lee Jong-Gyu, Yang Yeong-In, Kim Ji-Hyun, Ahn Ji-Hye, Baek Nam-In, Lee Kyung-Tae, Choi Jung-Hye, Eupatilin, a dietary flavonoid, induces G2/M cell cycle arrest in human endometrial cancer cells, Food and Chemical Toxicology, 49, 8, 2011. Crossref

  12. Choi Eun-Ju, Oh Hyun-Mee, Na Bo-Ra, Ramesh T. P., Lee Hyun-Ju, Choi Chang-Soo, Choi Suck-Chei, Oh Tae-Young, Choi Suck-Jun, Chae Jeong-Ryong, Kim Sang-Wook, Jun Chang-Duk, Eupatilin Protects Gastric Epithelial Cells from Oxidative Damage and Down-Regulates Genes Responsible for the Cellular Oxidative Stress, Pharmaceutical Research, 25, 6, 2008. Crossref

  13. Pierini Roberto, Gee Jennifer M., Belshaw Nigel J., Johnson Ian T., Flavonoids and intestinal cancers, British Journal of Nutrition, 99, E-S1, 2008. Crossref

  14. Réthy Borbála, Csupor-Löffler Boglárka, Zupkó István, Hajdú Zsuzsanna, Máthé Imre, Hohmann Judit, Rédei Tamás, Falkay George, Antiproliferative activity of Hungarian Asteraceae species against human cancer cell lines. Part I, Phytotherapy Research, 21, 12, 2007. Crossref

  15. Sheng Xia, Sun Yang, Yin Ye, Chen Ting, Xu Qiang, Cirsilineol inhibits proliferation of cancer cells by inducing apoptosis via mitochondrial pathway, Journal of Pharmacy and Pharmacology, 60, 11, 2010. Crossref

  16. Park Jong-Min, Han Young-Min, Lee Jin-Seok, Ko Kwang Hyun, Hong Sung-Pyo, Kim Eun-Hee, Hahm Ki-Baik, Nrf2-mediated mucoprotective and anti-inflammatory actions of <i>Artemisia</i> extracts led to attenuate stress related mucosal damages, Journal of Clinical Biochemistry and Nutrition, 56, 2, 2015. Crossref

  17. Song Hyun Ju, Shin Chang Yell, Oh Tae Young, Min Young Sil, Park Eon Sub, Sohn Uy Dong, Eupatilin with Heme Oxygenase-1-Inducing Ability Protects Cultured Feline Esophageal Epithelial Cells from Cell Damage Caused by Indomethacin, Biological and Pharmaceutical Bulletin, 32, 4, 2009. Crossref

  18. Lee Do-Hoon, Park Kwang-Il, Park Hyeon-Soo, Kang Sang-Rim, Nagappan Arulkumar, Kim Jin-A, Kim Eun-Hee, Lee Won-Sup, Hah Young-Sool, Chung Hyon-Jong, An Su-Jin, Kim Gon-Sup, Flavonoids Isolated from KoreaCitrus aurantiumL. Induce G2/M Phase Arrest and Apoptosis in Human Gastric Cancer AGS Cells, Evidence-Based Complementary and Alternative Medicine, 2012, 2012. Crossref

  19. Bora Kundan Singh, Sharma Anupam, The GenusArtemisia: A Comprehensive Review, Pharmaceutical Biology, 49, 1, 2011. Crossref

  20. Choi Eun-Ju, Oh Hyun-Mee, Wee Hyun, Choi Chang-Soo, Choi Suck-Chei, Kim Ki-Hoon, Han Weon-Cheol, Oh Tae-Young, Kim Sang-Hyun, Jun Chang-Duk, Eupatilin exhibits a novel anti-tumor activity through the induction of cell cycle arrest and differentiation of gastric carcinoma AGS cells, Differentiation, 77, 4, 2009. Crossref

  21. Min Sung-Won, Kim Nam-Jae, Baek Nam-In, Kim Dong-Hyun, Inhibitory effect of eupatilin and jaceosidin isolated from Artemisia princeps on carrageenan-induced inflammation in mice, Journal of Ethnopharmacology, 125, 3, 2009. Crossref

  22. Cho H.-J., Kim J.-W., Ju S.-Y., Park Yoo-Kyoung, Effects of Artemisia princeps supplementation on bone metabolism in ovariectomized rats, The journal of nutrition, health & aging, 20, 5, 2016. Crossref

  23. Taghizadeh Rabe Shahrzad Zamanai, Mahmoudi Mahmoud, Ahi Ali, Emami Seyed Ahmad, Antiproliferative effects of extracts from IranianArtemisiaspecies on cancer cell lines, Pharmaceutical Biology, 49, 9, 2011. Crossref

  24. Lee Soyoung, Lee Myeungsu, Kim Sang-Hyun, Eupatilin inhibits H2O2-induced apoptotic cell death through inhibition of mitogen-activated protein kinases and nuclear factor-κB, Food and Chemical Toxicology, 46, 8, 2008. Crossref

  25. Zana Annamária, Hajdú Zsuzsanna, Jedlinszki Nikoletta, Máthé Imre, Dombi György, Hohmann Judit, Isolation and structural determination of new metabolites from Artemisia asiatica roots, Tetrahedron, 71, 29, 2015. Crossref

  26. Lee H. S., Ji H. Y., Park E. J., Kim S. Y., In vitrometabolism of eupatilin by multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes, Xenobiotica, 37, 8, 2007. Crossref

  27. Arundina Ira, Budhy S. Theresia Indah, Nirwana Intan, Indrawati Retno, Luthfi Muhammad, Toxicity Test n-Hexane: Ethyl Acetate (3:7) Fraction of Sudamala (Artemisia vulgaris L.), Procedia Chemistry, 18, 2016. Crossref

  28. Du Lei, Chen Jia, Xing Yi-qiao, Eupatilin prevents H2O2-induced oxidative stress and apoptosis in human retinal pigment epithelial cells, Biomedicine & Pharmacotherapy, 85, 2017. Crossref

  29. Zhou Di, Chen Gang, Wang Jian, Li Ning, Natural Cancer Chemopreventive Reagents from Food and Herbals, Current Pharmacology Reports, 3, 3, 2017. Crossref

  30. Li Feng, Tao Ya, Qiao Yan, Li Ke, Jiang Yanan, Cao Chang, Ren Shuxin, Chang Xiaobin, Wang Xiaona, Wang Yanhong, Xie Yifei, Dong Ziming, Zhao Jimin, Liu Kangdong, Eupatilin inhibits EGF-induced JB6 cell transformation by targeting PI3K, International Journal of Oncology, 49, 3, 2016. Crossref

  31. WANG YAWEI, HOU HONGWEI, LI MING, YANG YANG, SUN LAN, Anticancer effect of eupatilin on glioma cells through inhibition of the Notch-1 signaling pathway, Molecular Medicine Reports, 13, 2, 2016. Crossref

  32. Nam Su Youn, Kim Joo Sung, Kim Jung Mogg, Lee Jong Yeul, Kim Nayoung, Jung Hyun Chae, Song In Sung, DA-6034, a Derivative of Flavonoid, Prevents and Ameliorates Dextran Sulfate Sodium–Induced Colitis and Inhibits Colon Carcinogenesis, Experimental Biology and Medicine, 233, 2, 2008. Crossref

  33. Ji Hye Young, Kim Sung Yeon, Kim Dong Kyun, Jeong Ji Hyun, Lee Hye Suk, Effects of Eupatilin and Jaceosidin on Cytochrome P450 Enzyme Activities in Human Liver Microsomes, Molecules, 15, 9, 2010. Crossref

  34. Geng Peiwu, Luo Xinhua, Peng Xiufa, Lin Zixia, Chen Wenhao, Zhang Jin, Wen Congcong, Hu Lufeng, Hu Siyi, Development and validation of UPLC–MS/MS method for determination of eupatilin in rat plasma and its application in a pharmacokinetics study, Acta Chromatographica, 30, 4, 2018. Crossref

  35. Mirzahosseini Golnoush, Manayi Azadeh, Khanavi Mahnaz, Safavi Maliheh, Salari Ali, Madjid Ansari Alireza, San’ati Hassan, Vazirian Mahdi, Bio-guided isolation of Centaurea bruguierana subsp. belangerana cytotoxic components, Natural Product Research, 33, 11, 2019. Crossref

  36. KIM M.-J., KIM D.-H., LEE K. W., YOON D.-Y., SURH Y.-J., Jaceosidin Induces Apoptosis in ras-Transformed Human Breast Epithelial Cells through Generation of Reactive Oxygen Species, Annals of the New York Academy of Sciences, 1095, 1, 2007. Crossref

  37. Ding Lin-Fen, Peng Li-Yan, Zhou Hao-Feng, Song Liu-Dong, Wu Xing-De, Zhao Qin-Shi, Artemilavanolides A and B, two sesquiterpenoids with a 6-oxabicyclo[3.2.1]octane scaffold from Artemisia lavandulaefolia, Tetrahedron Letters, 61, 21, 2020. Crossref

  38. Wu Zhao, Zou Bingyu, Zhang Xun, Peng Xue, Eupatilin regulates proliferation and cell cycle of cervical cancer by regulating hedgehog signalling pathway, Cell Biochemistry and Function, 38, 4, 2020. Crossref

  39. Mohammed Akram, Biegert Greyson, Adamec Jiri, Helikar Tomáš, Identification of potential tissue-specific cancer biomarkers and development of cancer versus normal genomic classifiers, Oncotarget, 8, 49, 2017. Crossref

  40. Lee Jin-Young, Bae Hyocheol, Yang Changwon, Park Sunwoo, Youn Byung-Soo, Kim Han-Soo, Song Gwonhwa, Lim Whasun, Eupatilin Promotes Cell Death by Calcium Influx through ER-Mitochondria Axis with SERPINB11 Inhibition in Epithelial Ovarian Cancer, Cancers, 12, 6, 2020. Crossref

  41. Jeong Seong Hun, Kim Jisu, Min Hyeyoung, In vitro anti-inflammatory activity of the Artemisia montana leaf ethanol extract in macrophage RAW 264.7 cells, Food and Agricultural Immunology, 29, 1, 2018. Crossref

  42. Lee Minkyeong, Yang Changwon, Song Gwonhwa, Lim Whasun, Eupatilin Impacts on the Progression of Colon Cancer by Mitochondria Dysfunction and Oxidative Stress, Antioxidants, 10, 6, 2021. Crossref

  43. Shahidi Fereidoon, Zhong Ying, Chandrasekara Anoma, Antioxidants and Human Health, in Cereals and Pulses, 2012. Crossref

  44. Lu Xiaochan, Deng Tingting, Dong Hongsong, Han Jinghong, Yu Yanping, Xiang Deng, Nie Guohui, Hu Bing, Zoratti Mario, Novel Application of Eupatilin for Effectively Attenuating Cisplatin-Induced Auditory Hair Cell Death via Mitochondrial Apoptosis Pathway, Oxidative Medicine and Cellular Longevity, 2022, 2022. Crossref

  45. Rashid Hasan M., Mahmod Asma Ismail, Afifi Fatma U., Talib Wamidh H., Antioxidant and Antiproliferation Activities of Lemon Verbena (Aloysia citrodora): An In Vitro and In Vivo Study, Plants, 11, 6, 2022. Crossref

  46. Polukonova Natalya V., Navolokin Nikita A., Baryshnikova Maria A., Maslyakova Galina N., Bucharskaya Alla B., Polukonova Anna V., Examining Apoptotic Activity Of Gratiola Officinalis L. (Scrophulariaceae) Extract On Cultured Human Tumor Cell Lines, Russian Open Medical Journal, 11, 4, 2022. Crossref

  47. Al Kury Lina T., Taha Zainab, Mahmod Asma Ismail, Talib Wamidh H., Xanthium spinosum L. Extracts Inhibit Breast Cancer in Mice by Apoptosis Induction and Immune System Modulation, Pharmaceuticals, 15, 12, 2022. Crossref

1860 Vistas de artículos 26 Descargas de artículos Métrica
1860 PUNTOS DE VISTA 26 DESCARGAS 47 Crossref CITAS Google
Scholar CITAS

Artículos con contenido similar:

Potential Anticancer Activity of the Parasol Mushroom, Macrolepiota procera (Agaricomycetes), against the A549 Human Lung Cancer Cell Line International Journal of Medicinal Mushrooms, Vol.20, 2018, issue 11
Canan Eroglu, Pelin Atmaca, Omer Faruk Colak, Mücahit Seçme, Oguzhan Kaygusuz, Yavuz Dodurga
Ipobscurine, an Indole Alkaloid from Ipomoea obscura, Inhibits Tumor Cell Invasion and Experimental Metastasis by Inducing Apoptosis Journal of Environmental Pathology, Toxicology and Oncology, Vol.30, 2011, issue 2
T. P. Hamsa, Girija Kuttan
Molecular Targets of Nimbolide for Anti-Cancer Therapy: An Updated Review Journal of Environmental Pathology, Toxicology and Oncology, Vol.41, 2022, issue 2
Subramanian Raghunandhakumar, Perumal Elumalai, Devaraj Ezhilarasan
Antitumor Effects of Extract of the Oak Bracket Medicinal Mushroom, Phellinus baumii (Agaricomycetes), on Human Melanoma Cells A375 In Vitro and In Vivo International Journal of Medicinal Mushrooms, Vol.22, 2020, issue 2
Qian Chen, Ning Li , Wei-Li Lu, Yue Yang, Lan Zhang
Cytotoxicity of Medicinal Mushrooms Oudemansiella canarii and Ganoderma lucidum (Agaricomycetes) Against Hematologic Malignant Cells via Activation of Apoptosis-Related Markers International Journal of Medicinal Mushrooms, Vol.24, 2022, issue 11
Sofronio P. Kalaw, Braham Dhillon, Rich Milton R. Dulay, Seemanti Chakrabarti, Renato G. Reyes, Benigno C. Valdez, Esperanza C. Cabrera

Último edicion

A Review on Protease Inhibitors of Herbal Origin to Combat Malignancy Sanjib Bhattacharya Molecular Pathogenesis, Organ Metastasis, and Targeted Therapy for Non-Small-Cell Lung Cancer Salik Abdullah, Ratul Chakraborty, Pratiksha Somnath Kumkar, Biplab Debnath, Asis Bala Treatment Strategy for Breast Benign Intraductal Papilloma: A Meta-Analysis Congkun Lou, Wenhsin Wang, Binggang Zhou Prognostic Significance of Iron Metabolism and Immune-Related Genes as Risk Markers in Hepatocellular Carcinoma Shijing Tang, Hao Chen RNF20 Reduces Cell Proliferation and Warburg Effect by Promoting NLRP3 Ubiquitination in Liver Cancer Deqin Liu, Renyin Luo, Qian Zhou, Mei Li Development of a Prognostic Model for Gastric Cancer Based on Apoptosis- and Hypoxia-Related Genes: Predictive Insights into Survival and Immune Landscape Jian Zhu, Yao Ma

Próximos Artículos

LncRNA LINC01278 regulates the prognosis and related mechanisms of gastric cancer by targeting miR-129-5p Zhenhua Wang, Zhengliang Li, Xiaojing Liu, Jundong Wang, Jiaxi Wang, Guoxiang Jiang, Haizhou Yu FBXO45 expression levels Correlation with cancer severity by ZEB1 ubiquitin in non-small cell lung cancer Bingwei Dong LncRNA AGAP11 suppresses lung adenocarcinoma progression by miR-494-3p and predicts prognosis Ye He, Ya Lin , Chunge Dong, Jie Zhang, Yangli Zhu Treatment strategy for breast benign intraductal papilloma: A Meta-Analysis Congkun Lou, Wenxin Wang, Binggang Zhou Prognostic Significance of Iron Metabolism and Immune-Related Genes as Risk Markers in Hepatocellular Carcinoma Shijing Tang, Hao Chen Molecular Pathogenesis, Organ Metastasis, and Targeted Therapy for Non-Small Cell Lung Cancer (NSCLC) Salik Abdullah, Ratul Chakraborty, Pratiksha Somnath Kumkar, Biplab Debnath, Asis Bala A review on protease inhibitors of herbal origin to combat malignancy Sanjib Bhattacharya
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones Precios y Políticas de Suscripcione Begell House Contáctenos Language English 中文 Русский Português German French Spain